HPA009026

抗RRBP1抗体 ウサギ宿主抗体

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• 別名: 抗180kDaリボソームレセプターホモログ抗体 ウサギ宿主抗体, 抗ES/130関連タンパク質抗体 ウサギ宿主抗体, 抗リボソームレセプタータンパク質抗体 ウサギ宿主抗体, 抗リボソーム結合タンパク質1抗体 ウサギ宿主抗体
• UNSPSCコード: 12352203
• Human Protein Atlas Number: HPA009026
• NACRES: NA.43

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 製品種目: Prestige Antibodies^® Powered by Atlas Antibodies
• フォーム: buffered aqueous glycerol solution
• 交差性: human
• 強化検証: orthogonal RNAseq; independent; Learn more about Antibody Enhanced Validation
• テクニック: immunoblotting: 0.04-0.4 μg/mL; immunofluorescence: 0.25-2 μg/mL; immunohistochemistry: 1:2500-1:5000
• 免疫原配列: ELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREK
• UniProtアクセッション番号: Q9P2E9
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... RRBP1(6238)

詳細

詳細

RRBP1 (ribosome binding protein 1) is a membrane protein that localizes to endoplasmic reticulum (ER). It is also found in cytoplasm and nucleus. This protein is composed of 1410 amino acids, a transmembrane domain in its hydrophobic N-terminal, a highly conserved tandem repeat which functions as the ribosome-binding domain, and the C-terminal which contains an acidic coiled-coil domain.

免疫原

リボソ-ム結合タンパク質1のPrEST(recombinant protein epitope signature tag)抗原リコンビナントタンパク質。

アプリケーション

Prestige抗体^®は、Human Proteome Resource(HPR)プロジェクト(www.proteinatlas.org)によって開発・実証されたAtlas抗体です。抗体はすべて、数百の正常組織・疾病組織に対する免疫組織染色試験を行っています。これらの染色画像はHuman Protein Atlas(HPA)サイトで[Image Gallery]リンクをクリックするとご覧いただけます。さらに、ほとんどのPrestige抗体はプロテインアレイおよびウェスタンブロッティングの試験を行っています。試験のプロトコールおよびPrestige抗体、HPAに関する情報はsigma.com/prestigeをご覧ください。

生物化学的／生理学的作用

RRBP1 (ribosome binding protein 1) is a key ribosome binding protein and plays essential role in the translocation of naïve proteins across the membrane of endoplasmic reticulum (ER). It is essential for the terminal differentiation of secretory tissues, and for the production of pro-collagen in secretory tissues. It also functions as the interacting partner of the motor protein KIF5B (kinesin family member 5B), which is up-regulated in several cancer cell lines. RRBP1 protein is highly expressed in breast cancer (BC) cells and might have potential as a BC marker. This protein is essential for the ER-localization of bulk poly(A) and of certain mRNAs such as, placental alkaline phosphatase and calreticulin. Up-regulation of this protein promotes the progression of colorectal cancer, and functions as a predictor of poor outcome in post-operative cases. In secretory cells, RRBP1-rich ER is responsible for the expansion of trans-Golgi network following the secretion of activated collagen.

特徴および利点

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

関連事項

Corresponding Antigen APREST71890

物理的形状

PBS溶液 (pH 7.2, 40%グリセロ-ル, 0.02%アジ化ナトリウム含有)

法的情報

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)