おすすめの製品
関連するカテゴリー
詳細
Monoclonal anti-Human Haptoglobin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Haptoglobin (Hp) is a serum α 2-glycoprotein that exists as a tetramer, composed of two smaller identical α chains and two larger identical β chains. The α-chains are linked to each other by a disulfide bond and each β-chain is similarly linked to an α-chain. Plasma haptoglobin is structurally similar to serum immunoglobulins. Haptoglobin is found in normal plasma at a concentration of 0.3-1.9 mg/ml and accounts for 0.4-2.6% of the total plasma proteins. It is also one of the groups of plasma proteins known as acute phase reactants.
特異性
本抗体は、ヒトのハプトグロビンの3つの主要なハプロタイプ (1-1、 2-1、2-2型)に対して特異的です。ELISA法または免疫ブロット法において、本抗体は、ヒトIgG、トランスフェリン、C反応性タンパク質、α1 酸性糖タンパク質、アルブミン、ヘモグロビンと交差反応しません。本抗体は、ヒト血清中の精製抗原としてのヒトハプトグロビンを、あるいは非還元の天然または変性状態でヒトヘモグロブリンと複合体を形成している場合に認識します。
アプリケーション
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Monoclonal Anti-Haptoglobin antibody produced in mouse has been used in enzyme-linked immunosorbent assay (ELISA) to determine plasma haptoglobin (Hp) levels and to probe duplicate dot blot strips for dot blot assay. It has been used in affinity purification of human high-density lipoprotein (HDL) to obtain trypanosome lytic factor (TLF) and also to prepare an affinity resin.
生物化学的／生理学的作用
The most characteristic property of haptoglobin is its ability to form stable complexes with extra-corpuscular-free native hemoglobin that has been released during hemolysis and is thus thought to prevent iron loss through urinary excretion and to also prevent renal damage from the hemoglobin. In addition, the native form or normal plasma haptoglobin has been shown to exhibit a broad spectrum of immunosuppressive effects in the immune system. Measurement of haptoglobin levels may therefore be used to monitor the progress of inflammatory reactions and assess the efficiency of test drugs.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
適切な製品が見つかりませんか。
製品選択ツール.をお試しください
保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
H6395-BULK:
H6395-.2ML:
H6395-.5ML:
H6395-VAR:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Association of haptoglobin levels with age, parasite density, and haptoglobin genotype in a malaria-endemic area of Gabon
Fowkes FJI, et al.
The American Journal of Tropical Medicine and Hygiene, 74(1), 26-30 (2006)
Robert S Bresalier et al.
Gastroenterology, 127(3), 741-748 (2004-09-14)
Galectin-3 is a beta-galactoside-binding protein implicated in tumor progression and metastasis of colorectal cancers. To determine whether circulating galectin-3 ligands are related to the presence of colon cancer, we sought to identify and quantify ligands in serum that bind to
Plasma proteomic profile of sulfur mustard exposed lung diseases patients using 2-dimensional gel electrophoresis
Mehrani H, et al.
Clinical Proteomics, 8(1), 2-2 (2010)
Identification and purification of a hemoglobin-binding outer membrane protein from Neisseria gonorrhoeae.
Chen CJ, et al.
Infection and Immunity, 64(12), 5008-5014 (1996)
Human plasma protein N-glycosylation
Clerc F, et al.
Glycoconjugate Journal, 33(3), 309-343 (2016)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）