SRP6508

Haptoglobin (Phenotype 2-2) from human plasma

≥95% (SDS-PAGE)

• 別名: Hp 2-2
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• 由来生物: human plasma
• アッセイ: ≥95% (SDS-PAGE)
• フォーム: lyophilized
• 分子量: 170-900 kDa
• 包装: pkg of 1 mg
• UniProtアクセッション番号: P00738
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... HP(3240)

詳細

詳細

Haptoglobin(Hp) is an acute-phase antioxidant,[1] found abundantly in the plasma[2] , and it exhibits genetic polymorphism, that results in three genotypes namely Hp 1-1, Hp 1-2, and Hp 2-2.[1] The HP gene is mapped on the human chromosome at16q22.2.[3]

アプリケーション

Haptoglobin(Phenotype 2-2) from human plasma has been used as a mature form of haptoglobinto study its effects on human liver cancer cells.[4] It has also been used inthe preparation of the radiolabeled haptoglobin-hemoglobin (Hp-Hb) complex.[5]

生物化学的／生理学的作用

Haptoglobin (Hp)binds to the extra corpuscular hemoglobin in the plasma to avoid iron-mediatedoxidative tissue damage.[2] Haptoglobin2-2 (Hp 2-2) is the least effective of the three haptoglobin phenotypes inbinding free hemoglobin and therefore provides less antioxidant benefits thanHp 1-1.[6][7] Hp 2-2 is associated with renal failure, familial and post-traumatic epilepsy.[8] It isalso associated with hypertension, atherosclerosis, and coronary heart diseasesin patients with type II diabetes.[2] Individuals who are phenotype 2-2 have the lowest concentration ofhaptoglobin in plasma.[8]

物理的形状

Lyophilized as a salt-free solid.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable