H2539

Anti-HAP40 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 別名: Anti-Huntingtin-associated Protein 40kDa
• MDL番号: MFCD03791872
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~40 kDa
• 交差性: mouse
• テクニック: western blot: 1:500-1:1,000 using mouse brain
• UniProtアクセッション番号: Q00558
• 輸送温度: dry ice
• 保管温度: −20°C
• 遺伝子情報: mouse ... F8A1(14070)

詳細

詳細

Three sequence-identical paralogs of the factor VIII intronic transcript A (F8A) gene codes for huntingtin-associated protein 40 (HAP40) in humans. In amniotes, HAP40 is coded by a single-exon gene (SEG). The F8A or coagulation factor VIII-associated 1 (F8A1) gene is located on human chromosome Xq28.

免疫原

peptide corresponding to the mouse HAP40 protein (amino acids 314-325).

アプリケーション

Co-immunoprecipitates Huntingtin protein.

生物化学的／生理学的作用

Huntingtin-associated protein 40 (HAP40) acts as an effector of Ras-related protein 5 (Rab5) It interacts with huntingtin (HTT). HAP40 may participate in the abnormal nuclear localization of mutant huntingtin identified in Huntington′s disease degenerating neurons.

ターゲットの説明

HAP40 is a 40 kDa Huntingtin-associated protein. It islikely to contribute to the function of normal huntintinand is a candidate for involvement in the aberrantnuclear localization of mutant huntingtin found indegenerating neurons in Huntington′s

物理的形状

Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable