G8166

Glucagon-Like Peptide 2 -Arg human trifluoroacetate salt

>90% (HPLC), solid

• 別名: GLP-2-Arg, Preproglucagon 126-159
• 実験式（ヒル表記法）: C₁₇₁H₂₆₆N₄₈O₅₆S
• CAS番号: 99120-49-7
• 分子量: 3922.29
• MDL番号: MFCD00081649
• UNSPSCコード: 51111800
• NACRES: NA.32

特性

• 品質水準: 200
• アッセイ: >90% (HPLC)
• フォーム: solid
• UniProtアクセッション番号: P01275
• 保管温度: −20°C
• 遺伝子情報: human ... GCG(2641)

詳細

Amino Acid Sequence

His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-Arg

詳細

Glucagon-like peptide 2 (GLP-2) is a member of the pro-glucagon gene family which is released in small and large intestinal circulation by enteroendocrine L cells.[1] This peptide is composed of 33 amino acids.[2]

アプリケーション

Glucagon-Like Peptide 2 (GLP-2) -Arg human trifluoroacetate salt has been used for injection in chickens to determine the effects of GLP-2 on the weight and morphology of small intestines.[1]

生物化学的／生理学的作用

Glucagon-like peptide 2 (GLP-2) influences the functionality of gastrointestinal tract by participating in the feedback loop to the brain for the control of food intake. It also controls digestion and absorption, and has tropic effects post chemotherapy injury or surgical resection.[1] This peptide is also responsible for epithelial cell proliferation of the small bowel.[3] Studies in rats show that this peptide enhances the effects of the ileal-brake hormones, GLP-1 and peptide YY. It also negatively regulates gastrointestinal motility and secretion. Thus, it has potential as a therapeutic agent in short-bowel syndrome.[2]

Glucagon-like peptide 2 is a neuropeptide that inhibits food intake when injected into the lateral ventricles of the brain and may mediate satiety. It is also a growth factor that stimulates proliferation and blocks apoptosis of intestinal epithelial cells.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)