G5421

Monoclonal Anti-Granulocyte Colony Stimulating Factor antibody produced in rat

clone 67604, purified immunoglobulin, lyophilized powder

• 別名: Anti-Csf3, Anti-Csfg, Anti-G-CSF, Anti-MGI-IG
• UNSPSCコード: 51111800
• NACRES: NA.41

特性

• 由来生物: rat
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 67604, monoclonal
• フォーム: lyophilized powder
• 化学種の反応性: mouse
• テクニック: capture ELISA: 2-8 μg/mL; neutralization: suitable; western blot: 1-2 μg/mL
• アイソタイプ: IgG1
• UniProtアクセッション番号: P09920
• 保管温度: −20°C
• 遺伝子情報: mouse ... Csf3(12985)

詳細

詳細

Mature myeloid cells are derived from bone-marrow derived precursor cells by the activity of three colony stimulating factors, granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF) and granulocyte colony-stimulating factor (G-CSF). The expression of G-CSF is the result of activation of pathways in response to tumor necrosis factor-α, LPS and toll-like receptor ligands. The pathways that induce the effects of G-CSF are PI3K, ERK1/2 and p38. The generation of neutrophils and induction of the circulation of hematopoietic stem cells from the bone marrow are the main functions of G-CSF. There are additional activities attributed to G-CSF such as neuroprotection, immunomodulation and generation of cardiac cells and dendritic cells. Large quantities of G-CSF are secreted in a variety of myeloid and non-myeloid cancers and rheumatoid arthritis
Monoclonal anti-granulocyte colony stimulating factor recognizes mouse G-CSF. The antibody shows less than 0.06% cross-reactivity with recombinant human G-CSF.

免疫原

purified, recombinant mouse granulocyte colony stimulating factor, expressed in E. coli.

アプリケーション

Anti-granulocyte colony stimulating factor antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For ELISA the recommended concentration range is 2-8 μg/ml. The antibody is also suitable for neutralization assays.

物理的形状

凍結乾燥品(PBS溶液, 5%トレハロース含有, 0.2 μmフィルター滅菌済み)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)