F8304

フラボキサート 塩酸塩

≥98% (HPLC), solid

• 別名: 3-メチル-4-オキソ-2-フェニル-4H-1-ベンゾピラン-8-カルボン酸 2-(1-ピペリジニル)エチルエステル 塩酸塩, DW-61, Rec-7-0040
• 実験式（ヒル表記法）: C₂₄H₂₅NO₄ · HCl
• CAS番号: 3717-88-2
• 分子量: 427.92
• EC Number: 223-066-4
• MDL番号: MFCD00072099
• UNSPSCコード: 12352200
• PubChem Substance ID: 24724484
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 色: white
• 溶解性: H₂O: ~6.6 mg/mL
• オーガナイザー: Johnson & Johnson
• SMILES記法: Cl[H].CC1=C(Oc2c(cccc2C1=O)C(=O)OCCN3CCCCC3)c4ccccc4
• InChI: 1S/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25;/h2,4-5,8-12H,3,6-7,13-16H2,1H3;1H
• InChI Key: XOEVKNFZUQEERE-UHFFFAOYSA-N
• 遺伝子情報: human ... PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144) , PDE7A(5150) , PDE7B(27115) , PDE8A(5151) , PDE8B(8622)

詳細

生物化学的／生理学的作用

Flavoxate, a flavone derivative[1] and a tertiary-amine antimuscarinic[2] possess antispasmodic properties.[2] It is a strong smooth muscle relaxant[1] that selectively acts on the pelvic region[3] and is used in the symptomatic treatment of overactive bladder (OAB)[1] and incontinence.[2] Post-absorption in the gastrointestinal tract, flavoxate is localized in bladder, liver, and kidney tissues.[1] It mediates the inhibition of phosphodiesterase (PDE) in the urinary bladder.[1] Use of flavoxate aids pain relief in inflammatory disorders of the urinary tract.[3]

L-type Ca²⁺ (Ca_v1.2) channel inhibitor

特徴および利点

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H335
• 注意書き: P261 - P264 - P270 - P271 - P301 + P312 - P304 + P340 + P312
• 危険有害性の分類: Acute Tox. 4 Oral - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves