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50 μG
￥118,000
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￥118,000
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詳細
Factor V, a glycoprotein is usually seen in the alpha granules of platelets and in plasma.[1]
Factor Va is the activated form of factor V and the cofactor of Xa. It is a component of the prothrombinase complex.
生物化学的／生理学的作用
Factor V is a key component in blood coagulation systems, where deficiencies can inhibit thrombin generation and affect hemostasis. It has been used in studies of coagulopathic bleeding which occurs following injury and is a leading cause of hospital deaths.
Factor Va serves as a receptor and positive effector of factor Xa. Hence it can efficiently help in the conversion of prothrombin to thrombin.[2]
関連事項
View this factors role in the Coagulation Cascade
単位の定義
1 unitは、pH 7.4、37°Cで正常ヒト血漿1.0 mL中の第V因子活性と等しい酵素活性を示します。
物理的形状
50%(v/v)グリセロールと5 mM CaCl2を含む水溶液です。
免責事項
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
F0931-50UG-PW:
F0931-VAR:
F0931-50UG:
F0931-BULK:
Less Common Congenital Disorders of Hemostasis
Consultative Hemostasis and Thrombosis, 60-78 (2013)
The factor V activation paradox
Orfeo T, et al.
The Journal of Biological Chemistry, 279(19), 19580-19591 (2004)
Eliza A Ruben et al.
Blood, 139(24), 3463-3473 (2022-04-16)
The intrinsic and extrinsic pathways of the coagulation cascade converge to a common step where the prothrombinase complex, comprising the enzyme factor Xa (fXa), the cofactor fVa, Ca2+ and phospholipids, activates the zymogen prothrombin to the protease thrombin. The reaction
Eliza A Ruben et al.
Blood, 137(22), 3137-3144 (2021-03-09)
Coagulation factor V (fV) is the precursor of fVa, which, together with fXa, Ca2+, and phospholipids, defines the prothrombinase complex and activates prothrombin in the penultimate step of the coagulation cascade. We solved the cryogenic electron microscopy (cryo-EM) structures of
Sandro B Rizoli et al.
The Journal of trauma, 71(5 Suppl 1), S427-S434 (2011-12-17)
Coagulopathic bleeding is a leading cause of in-hospital death after injury. A recently proposed transfusion strategy calls for early and aggressive frozen plasma transfusion to bleeding trauma patients, thus addressing trauma-associated coagulopathy (TAC) by transfusing clotting factors (CFs). This strategy
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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