E9530

エリスロポエチン マウス由来

recombinant, expressed in NSO cells, ≥90% (SDS-PAGE), lyophilized powder, suitable for cell culture

• 別名: EPO
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD01867534

特性

• biological source: mouse
• Quality Segment: 200
• recombinant: expressed in NSO cells
• assay: ≥90% (SDS-PAGE)
• form: lyophilized powder
• potency: 1.030 ng/mL
• mol wt: ~36 kDa by SDS-PAGE, predicted mol wt 18.6 kDa
• packaging: pkg of 10 μg
• storage condition: avoid repeated freeze/thaw cycles
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, tested
• UniProt accession no.: P07321
• storage temp.: −20°C
• Gene Information: mouse ... Epo(13856)

詳細

General description

EPO (erythropoietin) gene is localized to human chromosome 7q22. This protein is predominantly produced by the cortex cells of kidney, as well as a variety of tissues including female reproductive organs. It is a glycoprotein, which has a molecular weight of 34kDa. It is produced as a 193-amino acid precursor protein, which is cleaved to produce a secreted protein of 166-amino acid.

Biochem/physiol Actions

EPO (erythropoietin) plays an essential role in the growth and differentiation of erythrocyte progenitor cells. It is involved in the pathogenesis of myomatous erythrocytosis syndrome, which is characterized by erythrocytosis and myomatous uterus. It acts as a ligand for a homodimer of EPO-receptor (Epo-R), which is localized to the surface of immature erythroid cells. This interaction leads to inhibition of apoptosis and facilitation of cell proliferation and differentiation to mature erythrocytes.

エリスロポエチンは、赤血球の成長および分化の主要な調節因子である糖タンパク質です。

Physical form

0.2 μmフィルタ-で濾過した、0.5 mg BSAを含有するリン酸緩衝生理食塩水の凍結乾燥品

Analysis Note

生物活性はTF-1細胞株を用いた細胞増殖刺激能力により評価しています。

安全性情報

• 保管分類: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)