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About This Item
実験式（ヒル表記法）:
C18H14O3
CAS番号:
分子量:
278.30
MDL番号:
UNSPSCコード:
12352200
PubChem Substance ID:
NACRES:
NA.25
現在、価格および在庫状況を閲覧できません。
おすすめの製品
由来生物
Salvia miltiorrhiza
アッセイ
≥98% (HPLC)
フォーム
powder
保管条件
protect from light
色
red
溶解性
ethanol: 1 mg/mL, clear, orange to red
アプリケーション
metabolomics
vitamins, nutraceuticals, and natural products
保管温度
2-8°C
SMILES記法
C[C@H]1COC(C2=C3C4=C(C=C2)C(C)=CC=C4)=C1C(C3=O)=O
InChI
1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1
InChI Key
HARGZZNYNSYSGJ-JTQLQIEISA-N
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詳細
DihydrotanshinoneI (DHTS) is a tanshinone derivative which is a soluble diterpene quinone pigment of danshen.
アプリケーション
Dihydrotanshinone I (DHTS) has been used:
- to study its cytocidal effects on chemosensitive ovarian cancer cells with or without platinum-based chemotherapy
- as a treatment to study its inhibitory effects on triple-negative breast cancer cells growth by modulating epithelial-mesenchymal transition (EMT) markers
- as a potential SARS-CoV-2 papain-like protease (PLpro) inhibitor
- as a human antigen R (HuR) inhibitor to study its role in Th17 cell differentiation related to autoimmune neuroinflammation
- as a reference standard to analyze Salvia miltiorrhiza Bunge extract (SME) components using high-performance liquid chromatography(HPLC)
生物化学的／生理学的作用
Dihydrotanshinone Iis a potent anti-cancer agent with its cytotoxic, apoptosis, cell cycle arresteffects and inhibition of angiogenesis, and metastasis in cancer cells. Italso exerts cardiovascular and cerebrovascular protective effects. DHTS isan anti-inflammatory, anti-ischemia-reperfusion (I/R), anti-allergic,anti-Alzheimer’s disease properties. It is also effective againstdrug-resistant cancer cells.
Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with mouse xenograft model.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
D0947-50MG:
D0947-VAR:
D0947-10MG:
D0947-BULK:
最新バージョンのいずれかを選択してください：
試験成績書（COA）
Lot/Batch Number
Daifei Wang et al.
Biopharmaceutics & drug disposition, 41(1-2), 54-63 (2020-01-17)
Salvia miltiorrhiza is one of the most commonly used traditional Chinese medicines in the treatment of cardiovascular and cerebrovascular diseases. Cryptotanshinone (CTS), tanshinone IIA (Tan IIA), dihydrotanshinone I (diTan I), and tanshinone I (Tan I) are the main active compounds
15,16-Dihydrotanshinone I, a Compound of Salvia miltiorrhiza Bunge, Induces Apoptosis through Inducing Endoplasmic Reticular Stress in Human Prostate Carcinoma Cells.
Chuang MT, Ho FM, Wu CC, Zhuang SY, Lin SY, Suk FM, Liang YC.
Evidence-Based Complementary and Alternative Medicine : ECAM, 2011 (2011)
Preet Lal et al.
Nucleic acids research, 45(16), 9514-9527 (2017-09-22)
The Human antigen R protein (HuR) is an RNA-binding protein that recognizes U/AU-rich elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post-transcriptionally regulates the fate of target RNAs. The natural product dihydrotanshinone-I (DHTS) prevents the association
Jing Chen et al.
Journal of immunology (Baltimore, Md. : 1950), 204(8), 2076-2087 (2020-03-15)
Dysregulated Th17 cell differentiation is associated with autoimmune diseases such as multiple sclerosis, which has no curative treatment. Understanding the molecular mechanisms of regulating Th17 cell differentiation will help find a novel therapeutic target for treating Th17 cell-mediated diseases. In
Shuai Ji et al.
Journal of pharmaceutical and biomedical analysis, 174, 367-375 (2019-06-17)
Fufang Danshen Dripping Pill (FDDP) and Clopidogrel Bisulfate Tablet (CBT) are usually combined for treatment of coronary artery diseases in clinical. To investigate the pharmacokinetic interaction between FDDP and CBT after oral administration of FDDP, CBT and their combination in
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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