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アッセイ
≥98%
フォーム
liquid
色
, clear colorless to yellow-green
密度
0.85 g/mL at 25 °C (lit.)
保管温度
2-8°C
SMILES記法
CCCC1CCCCN1
InChI
1S/C8H17N/c1-2-5-8-6-3-4-7-9-8/h8-9H,2-7H2,1H3
InChI Key
NDNUANOUGZGEPO-UHFFFAOYSA-N
アプリケーション
Coniine, a neurotoxic alkaloid from hemlock, is used in comparative analysis versus other alkaloids that act at the level of the nicotinic acid/nicotinic acetylcholine (nAChR) receptors.
その他情報
ドクニンジンの毒性成分です(ラセミ体)。
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 2 - Flam. Liq. 3
保管分類コード
3 - Flammable liquids
WGK
WGK 3
引火点(°F)
119.3 °F - closed cup
引火点(℃)
48.5 °C - closed cup
個人用保護具 (PPE)
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
消防法
第4類:引火性液体
第二石油類
危険等級III
非水溶性液体
Jan Code
C9392-BULK:
C9392-VAR:
C9392-1ML:
D Rizzi et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 6(12), 939-943 (1991-01-11)
In the past, hemlock poisoning was only known for its neurotoxic effects; quite recently non-neurological features, consisting of rhabdomyolysis and acute renal failure, have been also described. Here we report our experience with these clinical findings, which we frequently observe
T J Wilkinson et al.
Organic letters, 2(2), 155-158 (2000-05-18)
[reaction: see text] Sequences of lithiation-substitution, enantioselective hydrogenation, and diastereoselective lithiation-substitution provide efficient highly enantioselective syntheses of 2-substituted and cis and trans 2,6-disubstituted piperidines. The methodology is demonstrated by syntheses of (-)-coniine, (-)-solenopsin A, and (-)-dihydropinidine as their hydrochlorides.
F D Galey et al.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 4(1), 60-64 (1992-01-01)
Cattle in two herds developed signs of bloating, increased salivation and lacrimation, depression, respiratory distress, ataxia, and death after ingestion of hay that contained large amounts of poison hemlock (Conium maculatum). Twenty of 30 Angus cows and calves were affected
Nutrition borne myolysis; an uncommon cause of myolysis in Europe.
R Tzanetea et al.
Upsala journal of medical sciences, 105(3), 255-257 (2001-03-23)
J F Hayes et al.
Chemical communications (Cambridge, England), (18)(18), 1784-1785 (2002-09-21)
(S)-Coniine is made using a reaction which assembles the piperidine ring by the sequential formation of four new chemical bonds and installs the C-2 stereogenic centre with high levels of diastereocontrol (90% de).
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