C6617

CBIQ

≥98% (HPLC), solid

• 別名: 4-Chlorobenzo[f]isoquinoline
• 実験式（ヒル表記法）: C₁₃H₈NCl
• CAS番号: 32081-28-0
• 分子量: 213.66
• MDL番号: MFCD02179769
• UNSPSCコード: 12352200
• PubChem Substance ID: 24724450
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• 色: off-white
• 溶解性: DMSO: 15 mg/mL
• SMILES記法: Clc1nccc2c1ccc3ccccc23
• InChI: 1S/C13H8ClN/c14-13-12-6-5-9-3-1-2-4-10(9)11(12)7-8-15-13/h1-8H
• InChI Key: SHQLTRRYZVBEMR-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

CBIQ is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). CBIQ is a novel tool for a new ion channel; first activator of ΔF508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at ΔF508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis.

特徴および利点

This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS06,GHS05
• シグナルワード: Danger
• 危険有害性情報: H301,H315,H318,H335
• 注意書き: P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• 危険有害性の分類: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges