vial of 0.1 mL concentrate (478M-94) vial of 0.1 mL concentrate Research Use Only (478M-94-RUO) vial of 0.5 mL concentrate (478M-95) vial of 1.0 mL concentrate (478M-96) vial of 1.0 mL concentrate Research Use Only (478M-96-RUO) vial of 1.0 mL pre-dilute Research Use Only (478M-97-RUO) vial of 1.0 mL pre-dilute ready-to-use (478M-97) vial of 7.0 mL pre-dilute ready-to-use (478M-98) vial of 7.0 mL pre-dilute ready-to-use Research Use Only (478M-98-RUO)
Well-differentiated liposarcoma is a malignant, non-metastasizing tumor that can present with similar histological characteristics as benign lipoma lesions and has a higher recurrence rate. The CDK4 protein is frequently overexpressed in well-differentiated liposarcoma due to gene amplification of the 12q13-15 chromosomal region that harbors the CDK4 gene, but amplification and subsequent overexpression is rarely observed in lipomas. Due to CDK4 protein expression differences between these lesions, anti-CDK4 antibody can be used in an immunohistochemistry panel as an aid in the differential diagnosis between well-differentiated liposarcoma and lipoma.1,2,3
品質
United States - IVD Canada - RUO European Union - IVD Japan - RUO
物理的形状
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
Journal of clinical pathology, 62(12), 1127-1135 (2009-12-01)
Well differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas (DDLPS) have been shown to have supernumerary chromosomes with amplified sequences of the MDM2 and CDK4 genes. MDM2 and CDK4 protein overexpression have also been identified in these tumours. To investigate whether immunohistochemistry
The American journal of surgical pathology, 29(10), 1340-1347 (2005-09-15)
Atypical lipomatous tumor/well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) may be difficult to distinguish from benign adipose tumors and from poorly differentiated sarcomas, respectively. Genetically, they are characterized by amplification of MDM2 and CDK4 genes on chromosome 12q13-15. We examined
The American journal of surgical pathology, 36(3), 462-469 (2012-02-04)
Adipocytic tumors are the most common type of soft tissue neoplasms. Distinguishing atypical lipomatous tumor-well-differentiated liposarcoma (WDL) from benign adipocytic neoplasms and dedifferentiated liposarcoma (DDL) from pleomorphic or myxoid liposarcoma (LPS) can be difficult. WDL and DDL characteristically harbor amplifications
