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Merck
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主要文書

安全性情報

443R-1

Sigma-Aldrich

Nanog (EP225) Rabbit Monoclonal Primary Antibody

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About This Item

UNSPSCコード:
12352203

由来生物

rabbit

結合体

unconjugated

抗体製品の状態

culture supernatant

抗体製品タイプ

primary antibodies

クローン

EP225, monoclonal

詳細

For In Vitro Diagnostic Use in Select Regions

フォーム

buffered aqueous solution

化学種の反応性

human

包装

vial of 0.1 mL concentrate (443R-14)
vial of 0.1 mL concentrate Research Use Only (443R-14-RUO)
vial of 0.5 mL concentrate (443R-15)
vial of 1.0 mL concentrate (443R-16)
vial of 1.0 mL concentrate Research Use Only (443R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (443R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (443R-17)
vial of 7.0 mL pre-dilute ready-to-use (443R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (443R-18-RUO)

メーカー／製品名

Cell Marque®

テクニック

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 (concentrated)

アイソタイプ

IgG

コントロール

seminoma

輸送温度

wet ice

保管温度

2-8°C

視覚化

nuclear

遺伝子情報

human ... NANOG(79923)

関連するカテゴリー

詳細

Nanog is a transcription factor homeoprotein that is involved in maintaining embryonic stem cell pluripotency and self-renewal.[1][2][3] Embryonic stem cells with a deleted Nanog gene lose pluripotency. Conversely, embryonic stem cells that are forced to differentiate will downregulate Nanog expression.[1][2] Nanog expression has been shown to be absent in normal adult organ tissues, but positive expression in undifferentiated germ cell tumors such as seminoma, dysgerminoma and embryonal carcinoma has been noted.[1][2][4][5] Therefore, Nanog may be used as an aid in the determination of undifferentiated tumors of germ cell origin from non-germ cell tumors.[4][5]

品質


IVD
IVD
IVD
RUO

物理的形状

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

調製ノート

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その他情報

For Technical Service please contact: 800-665-7284 or email: [email protected]

法的情報

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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保管分類コード

12 - Non Combustible Liquids

WGK

WGK 2

引火点(°F)

Not applicable

引火点(℃)

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

443R-14-RUO:
443R-16:
443R-16-RUO:
443R-14:
443R-12:
443R-18-RUO:
443R-17-RUO:
443R-13:
443R-18:
443R-15:
443R-15-RUO:
443R-11:
443R-17:

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試験成績書（COA）

Lot/Batch Number

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以前この製品を購入いただいたことがある場合

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文書ライブラリにアクセスする

Adam H Hart et al.
Cancer, 104(10), 2092-2098 (2005-10-06)
The NANOG gene, a member of the homeobox family of DNA binding transcription factors, was recently identified in a screen for pluripotency-promoting genes. NANOG overexpression in murine embryonic stem cells is sufficient to maintain self-renewal and to block differentiation. The
Martin C Chang et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 28(4), 347-355 (2009-06-02)
The embryonic stem cell transcription factors SOX2, NANOG, and OCT3/4 are involved in the regulation of germ cell tumor growth and differentiation. They, and D2-40 (podoplanin), an antigen expressed in seminomas, are emerging as useful diagnostic markers in testicular germ
Ian Chambers et al.
Cell, 113(5), 643-655 (2003-06-06)
Embryonic stem (ES) cells undergo extended proliferation while remaining poised for multilineage differentiation. A unique network of transcription factors may characterize self-renewal and simultaneously suppress differentiation. We applied expression cloning in mouse ES cells to isolate a self-renewal determinant. Nanog
Guangjin Pan et al.
Cell research, 17(1), 42-49 (2007-01-11)
Several extrinsic signals such as LIF, BMP and Wnt can support the self-renewal and pluripotency of embryonic stem (ES) cells through regulating the "pluripotent genes." A unique homeobox transcription factor, Nanog, is one of the key downstream effectors of these
Kaoru Mitsui et al.
Cell, 113(5), 631-642 (2003-06-06)
Embryonic stem (ES) cells derived from the inner cell mass (ICM) of blastocysts grow infinitely while maintaining pluripotency. Leukemia inhibitory factor (LIF) can maintain self-renewal of mouse ES cells through activation of Stat3. However, LIF/Stat3 is dispensable for maintenance of

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