Based on the information available, this version does recognize the epsilon subunit. This conclusion is drawn from the fact that the CD3 epsilon, also known as the cytoplasmic CD3 antibody, exhibits a cytoplasmic staining pattern with perinuclear Golgi accentuation and very rarely membranous. Typically, this antibody is utilized for identifying T cell and NK cell lymphomas in FFPE tissues (please refer to representative staining photos). While the Cd3 surface antibody is commonly used in flow cytometry for membranous CD3 detection, the CD3 epsilon cytoplasmic is generally used in FFPE tissue, as is often done for IHC.
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由来生物
rabbit
品質水準
100
500
結合体
unconjugated
抗体製品の状態
culture supernatant
抗体製品タイプ
primary antibodies
クローン
MRQ-39, monoclonal
詳細
For In Vitro Diagnostic Use in Select Regions (See Chart)
フォーム
buffered aqueous solution
交差性
human
包装
pkg of 0.1 mL concentrate (103r-94)
pkg of 0.5 mL concentrate (103R-95)
pkg of 1.0 mL concentrate (103R-96)
pkg of 1.0 mL predilute (103R-97)
pkg of 7.0 mL predilute (103R-98)
メーカー／製品名
Cell Marque®
体外診断薬
for in vitro diagnostic use
テクニック
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)
アイソタイプ
IgG1
コントロール
tonsil
輸送温度
wet ice
保管温度
2-8°C
視覚化
membranous
遺伝子情報
human ... CD3E(916)
詳細
Anti-CD3 has been considered the best all around T-cell marker. This antibody reacts with an antigen present in early thymocytes. The positive staining of this marker may represent a sign of early commitment to the T-Cell lineage.
品質
 IVD |  IVD |  IVD |  RUO |
関連事項
CD3 Positive Control Slides, Product No. 103S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
物理的形状
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
調製ノート
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
その他情報
For Technical Service please contact: 800-665-7284 or email: [email protected]
法的情報
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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試験成績書（COA）
Lot/Batch Number
SM Denning, et al.
Leucocyte Typing III, 144-147 (1987)
Kennosuke Karube et al.
The American journal of surgical pathology, 27(10), 1366-1374 (2003-09-26)
We studied the morphologic, immunohistochemical, and clinical characteristics of 158 cases of lymphoblastic lymphoma. Based on immunophenotyping and cell lineage, cases were classified into B-cell type (CD20,CD19 or CD79a+, n = 53), T-cell type (surface CD3+, n = 84), and
Ahmet Dogan et al.
The American journal of surgical pathology, 27(7), 903-911 (2003-06-27)
Occasionally, primary large B-cell lymphomas (LBLs) arising in the spleen present with a micronodular pattern involving the splenic white pulp but sparing the red pulp. Histologically, the nodules contain scattered large B cells in a background of numerous T cells
Ulla Axdorph et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 110(5), 379-390 (2002-06-22)
Morphologically, T-cell-rich B-cell lymphoma (TCRB-NHL) may be indistinguishable from Hodgkin's disease (HD). Immunophenotyping may be helpful in the separation of these entities. TCRB-NHL is occasionally misdiagnosed and treated as HD. However, information is limited regarding clinical characteristics and outcome of
E A Clark et al.
Immunology today, 10(7), 225-228 (1989-07-01)
During 1987, striking advances were made in defining the receptors and ligands for cell-to-cell adhesion interactions involving leukocytes. In 1988, two major leukocyte differentiation antigens, CD10 (cALLA) and CD45 (LCA, T200), were shown to be enzymes while two other markers
アクティブなフィルタ
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