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Merck
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資料

安全性情報

SMB00930

Sigma-Aldrich

5-Methoxy-L-tryptophan

98-102%

別名:

5-Methoxy-L-tryptophan, L-2-Amino-3-(5-methoxyindolyl)propionic acid

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About This Item

実験式（ヒル表記法）:
C12H14N2O3
CAS番号:
25197-96-0
分子量:
234.25
UNSPSCコード:
12352209
NACRES:
NA.26

品質水準

100

アッセイ

98-102%

形状

solid

光学活性

[α]20/D -30 to -28° in water

色

off-white to light yellow

保管温度

2-8°C

InChI

1S/C12H14N2O3/c1-17-8-2-3-11-9(5-8)7(6-14-11)4-10(13)12(15)16/h2-3,5-6,10,14H,4,13H2,1H3,(H,15,16)/t10-/m0/s1

InChI Key

KVNPSKDDJARYKK-JTQLQIEISA-N

詳細

5-Methoxy-L-tryptophan is a L-tryptophan metabolite that exhibits anti-inflammatory and tumor-suppressing activities. 5-Methoxy-L-tryptophan is synthesized by tryptophan hydroxylase (TPH) and hydroxyindole O-methyltransferase (HIOMT). A recent study indicates 5-methoxytryptophan as a biomarker of the progression of chronic kidney disease (CKD). Its levels decrease during disease and treatment with 5-methoxytryptophan ameliorates kidney fibrosis in mice model of CKD. 5-Methoxytryptophan appears to inhibit IκB/NFκB signaling and enhances Keap1/Nrf2 signaling in mice models of unilateral ureteral obstruction.

アプリケーション

5-Methoxy-L-tryptophan finds application in cell biology, biochemical and metabolomics research.

特徴および利点

  • Can be used in Metabolomics and Biochemical research
  • High-quality compound suitable for multiple research applications

その他情報

For additional information on our range of Biochemicals, please complete this form.

ピクトグラム

Skull and crossbones
GHS06

シグナルワード

Danger

危険有害性情報

H301

危険有害性の分類

Acute Tox. 3 Oral

保管分類コード

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

引火点(°F)

Not applicable

引火点(℃)

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

SMB00930-BULK:
SMB00930-100MG:
SMB00930-500MG:
SMB00930-250MG:
SMB00930-1G:
SMB00930-VAR:

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試験成績書（COA）

Lot/Batch Number
0000369622
0000364210
0000369622
0000364210
0000248294

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以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Hua-Ling Chen et al.
The Journal of biological chemistry, 293(28), 11131-11142 (2018-05-26)
5-Methoxytryptophan (5-MTP) is a tryptophan metabolite with recently discovered anti-inflammatory and tumor-suppressing activities. Its synthesis is catalyzed by a hydroxyindole O-methyltransferase (HIOMT)-like enzyme. However, the exact identity of this HIOMT in human cells remains unclear. Human HIOMT exists in several
Huei-Hsuan Cheng et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(33), 13231-13236 (2012-08-02)
Cyclooxygenase-2 (COX-2) expression is induced by mitogenic and proinflammatory factors. Its overexpression plays a causal role in inflammation and tumorigenesis. COX-2 expression is tightly regulated, but the mechanisms are largely unclear. Here we show the control of COX-2 expression by
Dan-Qian Chen et al.
Nature communications, 10(1), 1476-1476 (2019-04-02)
Early detection and accurate monitoring of chronic kidney disease (CKD) could improve care and retard progression to end-stage renal disease. Here, using untargeted metabolomics in 2155 participants including patients with stage 1-5 CKD and healthy controls, we identify five metabolites

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