PHR3069

オロパタジン 塩酸塩

pharmaceutical secondary standard, certified reference material

• 別名: (11Z)-11-[3-(ジメチルアミノ)プロピリデン]-6,11-ジヒドロジベンゾ[b,e]オキセピン-2-酢酸 塩酸塩, AL-4943A, KW-4679, オパタノール, パタノール
• 実験式（ヒル表記法）: C₂₁H₂₃NO₃·HCl
• CAS番号: 140462-76-6
• 分子量: 373.87
• MDL番号: MFCD00875716
• UNSPSCコード: 41116107
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 認証: traceable to USP 1478403
• CofA: current certificate can be downloaded
• 包装: pkg of 300 mg
• アプリケーション: pharmaceutical
• SMILES記法: Cl.CN(C)CC\C=C1\c2ccccc2COc3ccc(CC(O)=O)cc13
• InChI: 1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;
• InChI Key: HVRLZEKDTUEKQH-NOILCQHBSA-N

詳細

詳細

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

アプリケーション

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

オロパタジンは、ヒスタミンH1受容体拮抗薬であり、マスト細胞安定化剤でもあります。脳内におけるH1受容体の占有率の低さが、オロパタジンの鎮静作用の低さの理由となっています。オロパタジンはP-糖タンパク質の基質であり、それが脳への浸透を限定していると考えられています。

アナリシスノート

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAA6959(changes by product) in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• ピクトグラム: GHS06,GHS09
• シグナルワード: Danger
• 危険有害性情報: H301,H400
• 注意書き: P264 - P270 - P273 - P301 + P310 - P391 - P405
• 危険有害性の分類: Acute Tox. 3 Oral - Aquatic Acute 1
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable