PHR1855

テルミサルタン

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: テルミサルタン, 4'[(1,4′-ジメチル-2′-プロピル[2,6′-ビ-1H-ベンゾイミダゾール]-1′-イル)メチル][1,1′-ビフェニル]-2-カルボン酸, BIBR 277
• 実験式（ヒル表記法）: C₃₃H₃₀N₄O₂
• CAS番号: 144701-48-4
• 分子量: 514.62
• MDL番号: MFCD00918125
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823632
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to Ph. Eur. Y0000648; traceable to USP 1643419
• APIファミリー: telmisartan
• CofA: current certificate can be downloaded
• 包装: pkg of 500 mg
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-8°C
• SMILES記法: CCCc1nc2c(C)cc(cc2n1Cc3ccc(cc3)-c4ccccc4C(O)=O)-c5nc6ccccc6n5C
• InChI: 1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
• InChI Key: RMMXLENWKUUMAY-UHFFFAOYSA-N
• 遺伝子情報: human ... AGTR1(185)

詳細

詳細

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Telmisartan belongs to the class of angiotensin II receptor antagonists (ARAs) used in the treatment of hypertension.

アプリケーション

This pharmaceutical secondary standard can also be used as follows:

• Reversed-phase high-performance liquid chromatography (RP-HPLC) method-based multi-analysis of rosuvastatin, telmisartan, ezetimibe, and atorvastatin in pharmaceutical dosage formulations[1]
• RP-HPLC analysis of telmisartan in the presence of its three impurities in its tablet formulation following an analytical quality-by-design (AQbD) approach[2]
• Multi-determination of hydrochlorothiazide, amlodipine, and telmisartan by HPLC combined with spectrometric techniques without derivatization
• Simultaneous estimation of telmisartan and hydrochlorothiazide by micellar high-pressure liquid chromatography and spectrophotometry-based methods in their combined tablet formulations[3]
• RP-HPLC method-based determination of four cardiovascular drugs—atorvastatin, simvastatin, telmisartan, and irbesartan in bulk drugs and tablet dosage forms, following ICH guidelines

生物化学的／生理学的作用

AT₁アンジオテンシンレセプタ-の非ペプチド性アンタゴニストです。

アナリシスノート

このような2次標準は、入手可能な場合にはUSP、EP、BPの1次標準にマルチトレーサビリティを提供します。

脚注

To see an example of a Certificate of Analysis for this material enter LRAC3179 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable