PHR1602

ロサルタンカリウム

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: 2-ブチル-4-クロロ-1-[[2′-(2H-テトラゾール-5-イル)[1,1′-ビフェニル]-4-イル]メチル]-1H-イミダゾール-5-メタノール カリウム塩, 2-ブチル-4-クロロ-1-{[2′-(1H-テトラゾール-5-イル)(1,1′-ビフェニル)-4-イル]メチル}-1H-イミダゾール-5-メタノール 一カリウム塩, DuP 753, MK954, カリウム 5-(4′-((2-ブチル-4-クロロ-5-(ヒドロキシメチル)-1H-イミダゾール-1-イル)メチル)-[1,1′-ビフェニル]-2-イル)テトラゾール-1-イデ
• 実験式（ヒル表記法）: C₂₂H₂₂ClKN₆O
• CAS番号: 124750-99-8
• 分子量: 461.00
• Beilstein: 5845770
• MDL番号: MFCD02092704
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823502
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to BP 867; traceable to Ph. Eur. Y0001062; traceable to USP 1370462
• APIファミリー: losartan
• CofA: current certificate can be downloaded
• 包装: pkg of 1 g
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-30°C
• SMILES記法: CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]
• InChI: 1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
• InChI Key: OXCMYAYHXIHQOA-UHFFFAOYSA-N
• 遺伝子情報: human ... AGTR1(185)

詳細

詳細

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Losartan Potassium is a novel class of orally active, non-peptide angiotensin II (type AT₁) receptor antagonist drug that can be used in the remedy of hypertension. It exhibits superior activity than many other peptide receptor antagonist drugs and angiotensin converting enzyme (ACE) inhibitors owing to the high specificity, selectivity, and tolerability.

アプリケーション

Losartan Potassium may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques and spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

ロサルタンカリウムは、経口投与可能な強力かつ選択的な、競合的アンジオテンシンII受容体1型（AT1）アンタゴニストです。ロサルタンカリウムは高血圧の治療に使用されます。

アナリシスノート

このような2次標準は、入手可能な場合にはUSP、EP、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAC0141 in the slot below. This is an example certificate only and may not be the lot that you receive.

おすすめ製品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable