96408
N-(2-Phenylacetyl)glycine
analytical standard
別名:
2-(2-Phenylacetamido)acetic acid, 2-Phenylacetyl glycine, NSC 408424, NSC 92778, Phenaceturic acid, Phenacetylglycine
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About This Item
実験式（ヒル表記法）:
C10H11NO3
CAS番号:
分子量:
193.20
Beilstein:
1107116
MDL番号:
UNSPSCコード:
12352209
PubChem Substance ID:
NACRES:
NA.24
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グレード
analytical standard
品質水準
アッセイ
≥98.0% (HPLC)
シェルフライフ
limited shelf life, expiry date on the label
アプリケーション
clinical testing
フォーマット
neat
保管温度
2-8°C
SMILES記法
N(CC(=O)O)C(=O)Cc1ccccc1
InChI
1S/C10H11NO3/c12-9(11-7-10(13)14)6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,12)(H,13,14)
InChI Key
UTYVDVLMYQPLQB-UHFFFAOYSA-N
生物化学的／生理学的作用
Phenylacetylglycine is an acylglycine. Acylglycines are normally minor metabolites of fatty acids. However, the excretion of certain acylglycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acylglycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine ↔ CoA + N-acylglycine. Phenylacetylglycine or PAG is a glycine conjugate of phenylacetic acid. Phenylacetic acid may arise from exposure to styrene (plastic) or through the consumption of fruits and vegetables. Phenylacetic acid is used in some perfumes, possessing a honey-like odour in low concentrations, and is also used in penicillin G production. PAG is a putative biomarker of phospholipidosis. Urinary PAG is elevated in animals exhibiting abnormal phospholipid accumulation in many tissues and may thus be useful as a surrogate biomarker for phospholipidosis. The presence of phenylacetylglycine in urine has been confirmed for dogs, rats and mice. However, the presence of this compound in human urine is controversial. GC-MS studies have not found this compound while NMR studies claimed to have identified it , It appears that phenylacetylglycine may sometimes be mistaken for phenylacetylglutamine via NMR.
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シグナルワード
Warning
危険有害性情報
危険有害性の分類
Eye Irrit. 2
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
96408-50MG:
96408-BULK:
96408-10MG:
96408-250MG:
96408-VAR:
Xiuting Yu et al.
Experimental and therapeutic medicine, 14(2), 1184-1192 (2017-08-16)
The incidence of inflammatory bowel disease (IBD), characterized by chronic, relapsing intestinal inflammation, has continually increased in recent years. A previous study by our group identified five potential metabolic markers possibly associated with the pathology of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced IBD
Hudan Pan et al.
Frontiers of medicine, 13(5), 564-574 (2019-05-16)
Traditional Chinese medicine (TCM) formulas have attracted increasing attention worldwide in the past few years for treating complex disease including rheumatoid arthritis. However, their mechanisms are complex and remain unclear. Guan-Jie-Kang (GJK), a prescription modified from "Wu Tou Decoction," was
Jane Delaney et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 9(3), 271-290 (2005-03-15)
Amiodarone was given to male Sprague-Dawley rats at a dose of 150 mg kg(-1) day(-1) for 7 consecutive days to induce phospholipidosis in the lungs of treated rats. Amiodarone was given alone or concurrently with phenobarbitone. Animals given amiodarone had
M Matsumoto et al.
The Journal of veterinary medical science, 57(2), 205-211 (1995-04-01)
After the urine was treated with urease, lyophilized, and trimethylsilylated, it was examined for metabolic profiles in Dalmatian dogs and Shetland sheepdogs by gas chromatography-mass spectrometry (GC/MS), which simultaneously analyzes organic acids, amino acids, sugars, sugar alcohols, purine and pyrimidine
Bangjie Zhu et al.
Talanta, 207, 120256-120256 (2019-10-09)
Endogenous metabolites of amino acids and their derivatives in biosamples are frequently highlighted as the most differential metabolites in recent metabolomics studies. The method for the detection of amino acid derivatives such as N-acetyl amino acids and oligopeptides is rarely
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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