33894

クロトリマゾール

VETRANAL^®, analytical standard

• 別名: 1-(o-クロロ-α,α-ジフェニルベンジル)イミダゾール, 1-(o-クロロトリチル)イミダゾール, 1-[(2-クロロフェニル)ジフェニルメチル]-1H-イミダゾール
• 実験式（ヒル表記法）: C₂₂H₁₇ClN₂
• CAS番号: 23593-75-1
• 分子量: 344.84
• EC Number: 245-764-8
• MDL番号: MFCD00057220
• UNSPSCコード: 41116107
• PubChem Substance ID: 329754531
• NACRES: NA.24

特性

• グレード: analytical standard
• 製品種目: VETRANAL^®
• シェルフライフ: limited shelf life, expiry date on the label
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• 抗生物質活性スペクトル: fungi
• アプリケーション: agriculture; environmental
• フォーマット: neat
• 作用機序: protein synthesis | interferes
• SMILES記法: Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
• InChI: 1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
• InChI Key: VNFPBHJOKIVQEB-UHFFFAOYSA-N

詳細

詳細

Clotrimazole, a non-toxic, systemic, imidazole derivative[1] with broad-spectrum antimycotic activity, is primarily used in the treatment of oropharyngeal candidiasis.[2][3]

Its mode of action involves the inhibition of ergosterol synthesis, which leads to structural and functional damage of the cell membrane.[4]

アプリケーション

Clotrimazole may be used as a reference standard for the determination of the analyte in topical creams[1] and ear drops[5] by reversed-phase high-performance liquid chromatographic (RP-HPLC) method.[5]

Clotrimazole may be used as an analytical reference standard for the determination of the analyte in:

• Milk samples using solid-phase extraction followed by high-performance liquid chromatography (SPE-HPLC).[6]
• Environmental water samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS).[4]

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

法的情報

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07,GHS09
• シグナルワード: Warning
• 危険有害性情報: H302,H315,H319,H410
• 注意書き: P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves