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Merck
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資料

NXF-20

Millipore

Natrix® Qメンブレン吸着剤

別名:

Natrix® Q Membrane Adsorber

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About This Item

UNSPSCコード:
41115711
eCl@ss:
32011308

ligand

quaternary amine

品質水準

400

詳細

Natrix® Q Process 150

製品種目

Natrix®

パラメーター

0.6-3 L/min flow rate

ベッド高

0.5 mm

ベッド容積

115 mL

マトリックス活性基

Macroporous polymer

ポアサイズ

0.4 μm pore size

キャパシティ

23 g binding capacity (BSA)(per device

per device)

分離法

strong anion exchange

輸送温度

ambient

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詳細

Strong anion exchange chromatography membrane design to purify biomolecules with a high density of quaternary amine ligand the enables fast flow rates and high throughput at high loads while maintaining excellent impurity reduction
With a revolutionary three-dimensional macroporous hydrogel structure that provides a high density of binding sites and rapid mass transfer, Natrix®chromatography membranes deliver binding capacity that exceeds resin-based columns with fast flow rates typical of traditional membrane adsorbers. This combination of performance and speed in a single-use, plug-and-play device format enables low-risk, scalable solutions for efficient biomolecule purification

Natrix® Q chromatography membrane is a high productivity strong anion exchange membrane designed for biomolecule purification. The unique Natrix® Q chromatography membrane is a porous polyacrylamide hydrogel containing a high density of pendant quaternary ammonium (Q) binding groups that are directly polymerized within the an inert, macroporous membrane scaffold. The interconnected pore structure and high functional group density enables fast flow rates (seconds of residence time) with impressive throughput to extremely high loads while maintaining excellent impurity reduction across a wide range of buffer conditions. The Natrix® Q chromatography membrane design delivers improvements in productivity, flexibility, and process robustness and economics for any bioprocess design. The Natrix® Q Process 150 is process scale device designed for full-scale clinical and commercial manufacturing.

mAb nominal polishing capacity: 1150 g
Membrane configuration: Pleated

1 device per package

特徴および利点

Natrix® Q membrane adsorber provides users with:

  • High density of quaternary amine binding sites enabling rapid mass transfer
  • High binding capacity even at fast flow rates
  • Combination of performance and speed in, single use, plug-and-play device format enables low risk, scalable solutions for efficient biomolecule purification.

包装

Double bagged

法的情報

NATRIFLO is a trademark of Merck KGaA, Darmstadt, Germany
NATRIX is a registered trademark of Merck KGaA, Darmstadt, Germany

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試験成績書（COA）

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Mochao Zhao et al.
Vaccine, 37(36), 5491-5503 (2018-04-09)
Affinity chromatography is among the most powerful separation techniques, achieving the finest separation with high yields even in the most challenging feed streams. Incorporating affinity chromatography in vaccine purification has long been attempted by researchers to improve unit yield and
Renaud Jacquemart et al.
Computational and structural biotechnology journal, 14, 309-318 (2016-08-30)
The current processing paradigm of large manufacturing facilities dedicated to single product production is no longer an effective approach for best manufacturing practices. Increasing competition for new indications and the launch of biosimilars for the monoclonal antibody market have put
Ying Hou et al.
Biotechnology progress, 31(4), 974-982 (2015-05-29)
Protein A chromatography is widely employed for the capture and purification of monoclonal antibodies (mAbs). Because of the high cost of protein A resins, there is a significant economic driving force to seek new downstream processing strategies. Membrane chromatography has

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Robust, load independent viral clearance in monoclonal antibody purification with Natrix® Q chromatography membrane

Membrane adsorbers are a cost-effective, robust, single-use solution for monoclonal antibody polishing

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