Integrin beta 1is also known as CD29. It is a transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits, forming the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions such as hemostasis, embryonic development, wound repair, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Clone HM beta 1.1 is reported to inhibit beta 1 integrin mediated adhesion.
特異性
Other species have not been tested.
免疫原
Epitope: Full length
Purified mouse VLA-4 antigen
アプリケーション
Research Category 細胞骨格
Research Sub Category インテグリン
Detect Integrin beta1 using this Anti-Integrin beta1 Antibody, clone HM beta 1.1 validated for use in IC.
品質
Routinely evaluated by immunocytochemistry on mouse NIH3T3, A431 cells.
ターゲットの説明
130 kDa
物理的形状
Protein G Purified
Format: Purified
Purified in PBS with 0.05% NaN3.
保管および安定性
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
アナリシスノート
Control NIH3T3, A431
その他情報
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
American journal of physiology. Renal physiology, 313(4), F1026-F1037 (2017-07-14)
The renal collecting duct (CD) contains two major cell types, intercalated (ICs) and principal cells (PCs). A previous report showed that deletion of β1-integrin in the entire renal CD causes defective CD morphogenesis resulting in kidney dysfunction. However, subsequent deletion
Langmuir : the ACS journal of surfaces and colloids, 30(31), 9477-9483 (2014-07-24)
Functionalization of surfaces with poly(sodium styrenesulfonate) (poly(NaSS)) has recently been found to enhance osteointegration of implantable materials. Radical polymerization of poly(NaSS) on titanium (Ti)-based substrates has been used to improve their long-term performance by preventing fibrosis and consequently implant loosening.
