ABS551

Anti-Glucagon receptor Antibody

from rabbit, purified by affinity chromatography

• 別名: GL-R, Glucagon receptor
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 交差性: human
• 交差性（ホモロジーによる予測）: primate (based on 100% sequence homology)
• テクニック: immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBIアクセッション番号: NP_000151
• UniProtアクセッション番号: P47871
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... GCGR(2642)

詳細

詳細

Glucagon receptor or GL-R (UniProt P47871) is encoded by the GCGR (also known as GGR) gene (Gene ID 2642) in human. Glucagon is a 29-amino acid peptide that stimulates glycogenolysis and gluconeogenesis in the liver to increase blood glucose. The receptor for glucagon is a class 2 (or class B) G protein-coupled receptor (GPCR) that signals through Gs to stimulate cAMP production. Mice lacking the glucagon receptor have mild hypoglycemia after fasting and exhibit hyperplasia of pancreatic alpha-cells. Because of its role in promoting hyperglycemia, the glucagon receptor presents a potential target for treatment of diabetes.

免疫原

Epitope: Fourth cytoplasmic domain

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Glucagon receptor.

アプリケーション

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Glucagon receptor in human pancreas.

This Anti-Glucagon receptor Antibody is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Glucagon receptor.

品質

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected Glucagon receptor in 10 µg of human liver tissue lysate.

ターゲットの説明

~59 kDa observed. Target band appears larger than the calculated molecular weight of 54.0 kDa (Preform) and 51.3 kDa (mature) due to glycosylation. Lower molecular weight degradation band(s) can also be seen (Iwanij, V., et al. (1990). J. Biol Chem. 265(34):21302-21308).

その他情報

Concentration: Please refer to lot specific datasheet.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable