Reacts with proBDNF. Does not recognize mature BDNF isoforms.
免疫原
Fusion protein from mouse proBDNF containing only the prodomain region.
アプリケーション
Anti-Brain Derived Neurotrophic Factor Antibody, pro detects level of Brain Derived Neurotrophic Factor & has been published & validated for use in IP, WB, IH.
Western blot: 1:500-1:1,000. Reacts with bands of 30 kD and 28 kD.Immunohistochemistry: 1:100-1:250 on frozen sections.
Immunohistochemistry: 1:100-1:200
Immunoprecipitation: 1:100
Optimal working dilutions must be determined by the end user.
物理的形状
Chicken immunoglobulin. Liquid.
Format: Semi-Purified
法的情報
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
In both mice and patients with Albright hereditary osteodystrophy, heterozygous inactivating mutations of Gsα, a ubiquitously expressed G protein that mediates receptor-stimulated intracellular cAMP production, lead to obesity and insulin resistance but only when the mutation is present on the
Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice.
Astrocytes are the most abundant cell type in the brain and they make close contacts with neurons and blood vessels. They respond dynamically to various environmental stimuli and change their morphological and functional properties. Both physiological and pathological stimuli can
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(28), 11464-11478 (2013-07-12)
In the adult rodent brain, the olfactory bulb (OB) is continuously supplied with new neurons which survival critically depends on their successful integration into pre-existing networks. Yet, the extracellular signals that determine the selection which neurons will be ultimately incorporated
Memory consolidation requires astrocytic microdomains for protein recycling; but whether this lays a mechanistic foundation for long-term information storage remains enigmatic. Here we demonstrate that persistent synaptic strengthening invited astrocytic microdomains to convert initially internalized (pro)-brain-derived neurotrophic factor (proBDNF) into