676490

VEGFR2_D1-7, Human, Recombinant, S. frugiperda

• 別名: Vascular Endothelial Growth Factor Receptor 2 _D1-7, Soluble KDR/Flk-1
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• アッセイ: ≥90% (SDS-PAGE)
• 品質水準: 100
• フォーム: lyophilized
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 溶解性: aqueous buffer: ≥100 μg/mL; water: ≥100 μg/mL
• 輸送温度: wet ice
• 保管温度: −70°C

詳細

詳細

Recombinant, human VEGFR-2 consisting of all 7 immunoglobulin-like extracellular domains, but lacking the single transmembrane region and the intracellular split tyrosine kinase domain expressed in S. frugiperda insect cells. Contains all of the domains necessary for high affinity binding to VEGF. VEGFR-2 has a lower affinity for VEGF165 than VEGFR-1. However, VEGFR-2 has a higher signaling activity and is reported to mediate almost all observed endothelial cell responses to VEGF, including the increased microvascular permeability and endothelial cell proliferation. VEGFR-2 requires heparin for binding VEGF165.

生物化学的／生理学的作用

Measured by the ability to inhibit VEGF165-induced proliferation in human umbilical vein endothelial (HUVE) cells

警告

Toxicity: Standard Handling (A)

物理的形状

Lyophilized from 100 mM NaCl, 25 mM MES, pH 5.5.

再構成

Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C. Avoid freeze/thaw cycles of solutions.

その他情報

Robinson, C.J., and Stringer, S.E. 2001 J. Cell Sci.114, 853.
Roeckl, W., et al. 1998. Exp. Cell Res.241, 161.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable