The stability of this material at -80°C has not been determined. In solid form, compounds are generally less sensitive to temperature, particularly for relatively short periods of time. It is likely that the quality has not been impacted. However this cannot be guaranteed. It would be up to the end user to determine the suitability for use.
製品584222は現在お客様の国では販売されていません。 製品に関するお問い合わせはこちら（テクニカルサービス）
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品質水準
詳細
RTECS - UW5798980
アッセイ
≥90% (TLC)
フォーム
solid
メーカー／製品名
Calbiochem®
保管条件
OK to freeze
desiccated (hygroscopic)
protect from light
色
white to off-white
溶解性
water: 200 mg/mL
輸送温度
wet ice
保管温度
−20°C
SMILES記法
N2(CCC(NC2=O)O)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO
InChI
1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1
InChI Key
UCKYOOZPSJFJIZ-XVKVHKPRSA-N
詳細
A potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies.
アプリケーション
- Oncotherapy resistance explained by Darwinian and Lamarckian models.: This research explores the mechanisms of oncotherapy resistance, combining Darwinian and Lamarckian models to provide a comprehensive understanding. The study highlights the role of Tetrahydrouridine in modulating therapy resistance pathways in cancer treatment (Saunthararajah et al., 2024).
- Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy.: This study investigates the potential of using Tetrahydrouridine in non-cytotoxic therapies for small cell lung cancers, focusing on neuroendocrine lineage commitment and its implications for treatment efficacy (Biswas et al., 2023).
- In Vitro Interaction of Tetrahydrouridine with Key Human Nucleoside Transporters.: This study explores how Tetrahydrouridine interacts with human nucleoside transporters, shedding light on its mechanisms of action and potential as a therapeutic agent in biochemistry and pharmacology (Säll et al., 2023).
- Mycoplasma infection of cancer cells enhances anti-tumor effect of oxidized methylcytidines.: This research investigates how mycoplasma infection enhances the anti-tumor effects of oxidized methylcytidines, with Tetrahydrouridine playing a crucial role in the observed therapeutic outcomes (Pang et al., 2023).
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
再構成
Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Aqueous stock solutions (at neutral or basic pH) are stable for up to 3 months at -20°C.
その他情報
Yusa, K., et al. 1995. Biochem. Biophys. Res. Commun. 206, 486.
Bouffard, D.Y., et al. 1993. Biochem Pharmacol.45, 1857.
Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol.30, 7.
Riva, C., et al. 1992. Chemotherapy38, 358.
Yusa, K., et al. 1992. J. Biol. Chem. 267, 16848.
Hanze, A.R. 1967. J. Am. Chem. Soc.89, 6720.
Bouffard, D.Y., et al. 1993. Biochem Pharmacol.45, 1857.
Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol.30, 7.
Riva, C., et al. 1992. Chemotherapy38, 358.
Yusa, K., et al. 1992. J. Biol. Chem. 267, 16848.
Hanze, A.R. 1967. J. Am. Chem. Soc.89, 6720.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
584222-500MG:
584222-5GM:
584222-VMG:
584222-1.1ML:
584222-10UNMG:
584222-100MG:
584222-10MG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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Dear partener, Kindly advice if THU 10 mg vials sored at -80 for 3 days can be used. Thank you,
1 回答-
役に立ちましたか？
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Hi, may I ask if the THU (Cat number: 18771-50-1) is stable if stored at -4 oC and 10 oC? There is temperature excursion of the freezer in lab, and we would like to check what is the highest tolerable storage Temp which this reagent stored
1 回答-
The recommended storage temperature for this material is −20°C. The product is shipped on ice to maintain the quality of the compound. In general, products of this nature are considered stable within the range of −10 to 25°C. The end user would have to evaluate the integrity of the product for excursions beyond this range.
役に立ちましたか？
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Does this product have an expiry date?
1 回答-
This product does not contain an expiration date. It contains a recommended retest date of 10 years after the quality release date. A recommended retest date is the period of time during which the product is expected to remain within established stability specifications, provided that it has been stored under defined conditions. After the Retest Date, product samples should be examined to ensure that the product is still in compliance with the established specifications. For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/quality-services
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アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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