おすすめの製品
アッセイ
≥99% (HPLC)
品質水準
形状
solid
メーカー／製品名
Calbiochem®
保管条件
OK to freeze
protect from light
色
white
溶解性
water: 100 mM
保管温度
2-8°C
InChI
1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
InChI Key
ZJQHPWUVQPJPQT-UHFFFAOYSA-N
詳細
A constituent and psychoactive ingredient of the mushroom Amanita muscariathat acts as a potent agonist of GABAA receptors (EC50 = 28 µM and 33 µM in neonatal and adult rats, respectively), with preferential efficacy and selectivity to high-affinity receptor subtypes. Shown to be permeate the blood-brain barrier. Impairs associate and memory functions.
生物化学的／生理学的作用
Primary Target
GABAA
GABAA
警告
Toxicity: Toxic (F)
再構成
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
その他情報
Chandra, D., et al. 2010. Neuropsychopharmacology.35, 999.
Fischer, H., et al. 2005. J. Physiol.564, 465.
Ramirez, D.R., et al. 2005. Neurobiol. Learning and Memory.84, 184.
Fischer, H., et al. 2005. J. Physiol.564, 465.
Ramirez, D.R., et al. 2005. Neurobiol. Learning and Memory.84, 184.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Acute Tox. 2 Oral - STOT SE 3
ターゲットの組織
Central nervous system
保管分類コード
6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Dev Chandra et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35(4), 999-1007 (2009-12-25)
Muscimol has been regarded as a universal agonist for all gamma-aminobutyric acid type A receptor (GABA(A)-R) subtypes. However, brain regional distribution of muscimol's high-affinity binding sites greatly differs from those of other binding sites of the GABA(A)-R. To test whether
Donna R Ramirez et al.
Neurobiology of learning and memory, 84(3), 184-191 (2005-08-10)
A matching-to-position (MTP) paradigm was altered to influence the type of associations a rat would use to solve the task. Our main behavioral manipulation was the application of the differential outcomes procedure (DOP). The DOP involves correlating each to-be-remembered event
Harald Fischer et al.
The Journal of physiology, 564(Pt 2), 465-474 (2005-02-26)
The effects of gamma-aminobutyric acid (GABA) on the electrophysiological properties of intracardiac neurones were investigated in the intracardiac ganglion plexus in situ and in dissociated neurones from neonatal, juvenile and adult rat hearts. Focal application of GABA evoked a depolarizing
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