5.04713

CPCCOEt

• 別名: CPCCOEt, (E)-Ethyl 1,1a,7,7a-tetrahydro-7-(hydroxyimino)cyclopropa[b]chromene-1a-carboxylate, mGlu₁ Antagonist, CPCCOEt
• 実験式（ヒル表記法）: C₁₃H₁₃NO₄
• CAS番号: 179067-99-3
• 分子量: 247.25
• MDL番号: MFCD00947859
• UNSPSCコード: 12352200

特性

• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• フォーム: powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 100 mM
• 保管温度: 2-8°C
• InChI: 1S/C13H13NO4/c1-2-17-12(15)13-7-9(13)11(14-16)8-5-3-4-6-10(8)18-13/h3-6,9,16H,2,7H2,1H3/b14-11-
• InChI Key: FXCTZFMSAHZQTR-KAMYIIQDSA-N

詳細

詳細

A potent, negative allosteric modulator selective for mGlu₁ receptors (IC₅₀ = 6.5 µM). No effect on other mGlu subtype receptors and ionotropic glutamate receptors at concentrations less than 100 µM. Acts by inhibiting an intramolecular interaction between the agonist-bound extracellular domain and the transmembrane domain. Widely used for studies related to peripheral pain and central pain pathways.

生物化学的／生理学的作用

Primary Target
mGlu₁ receptors

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Luongo L, et al. 2013. Neuropharmacol.66, 317.

Jin, Y., et al. 2012. Pain Res. Treat.2012, 915706.
Tappe-Theodor, A., 2011. Mol Pain.7, 38.

Litschig, S., et al. 1999. Mol. Pharmacol.55, 453.
Annoura, H., et al. 1996. Bioorg. Med. Chem. Lett.6, 763.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable