5.04120

Reboxetine Mesylate

• 別名: Reboxetine Mesylate, (2R*)-2-[(R*)-(2-Ethoxyphenoxy)phenylmethyl]morpholine methanesulfonate, Edronax, Vestra
• 実験式（ヒル表記法）: C₁₉H₂₃NO₃ · xCH₄O₃S
• CAS番号: 98769-84-7
• 分子量: 313.39 (free base basis)
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥99% (HPLC)
• 品質水準: 100
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• 色: white
• 溶解性: water: 20 mg/mL
• 保管温度: 2-8°C
• InChI: 1S/C19H23NO3.CH4O3S/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m1./s1
• InChI Key: CGTZMJIMMUNLQD-STYNFMPRSA-N

詳細

詳細

A potent and selective inhibitor of noradrenalin uptake (K_i values are 1.1, 129 and >10000 nM for rat NET, SERT and DAT, respectively). Displays >1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant.

生物化学的／生理学的作用

Primary Target
Noradrenalin transporter

Target K_i: 1.1, 129 and >10000 nM for rat NET, SERT and DAT respectively

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze 9-20°C. Stock solutions are stable for up to 3 months at -20°C.

その他情報

Sacchetti, G., et al. 1999. Br. J. Pharmacol.128, 1332.

Wong, E., et al. 2000. Biol. Psychiatry.47, 818.
Millan, M., et al. 2001. J. Pharmacol. Exp. Ther.298,565.
Owen, J., et al. 2003 Neurosci. Lett.348, 171.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07,GHS08
• シグナルワード: Danger
• 危険有害性情報: H302 - H360D
• 注意書き: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• 危険有害性の分類: Acute Tox. 4 Oral - Repr. 1B
• 保管分類コード: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable