A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM)and protein kinase C (Ki = 42 µM) at much higher concentrations.
生物化学的／生理学的作用
Cell permeable: yes
Primary Target Myosin light chain kinase (Mlck)
Product competes with ATP.
Reversible: yes
Target Ki: 300 nM against myosin light chain kinase
警告
Toxicity: Standard Handling (A)
調製ノート
Further dilute with aqueous buffer just prior to use.
再構成
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
その他情報
Krarup, T., et al. 1998. Am. J. Physiol. 275, C239. Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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