407325

Interferon-α-IFNα-R Interaction Inhibitor

The Interferon-α-IFNα-R Interaction Inhibitor controls the biological activity of Interferon-α-IFNα-R.

• 別名: Interferon-α-IFNα-R Interaction Inhibitor, IFN-α Inhibitor, N-Methyl-1-(2-(naphthalen-1-ylthio)phenyl)methanamine, HCl, N-Methyl-N-(2-(1-naphthylthio)benzyl)amine, HCl, N-Methyl-1-(2-(naphthalen-1-ylthio)phenyl)methanamine, HCl, N-Methyl-N-(2-(1-naphthylthio)benzyl)amine, HCl, IFN-α Inhibitor
• 実験式（ヒル表記法）: C₁₈H₁₇NS · xHCl
• 分子量: 279.40 (free base basis)
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 色: white
• 溶解性: DMSO: 50 mg/mL, clear, colorless
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: CNCC1=CC=CC=C1SC2=CC=CC3=C2C=CC=C3.[xHCl]

詳細

詳細

A nonpeptidic thiophenylmethanamine compound that binds interferon-α (K_d = 4 µM for human IFN-α) and prevents IFN-α and IFNAR interaction-dependent IFN-α production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA (vaccinia virus Ankara) infection (IC₅₀<4.5 µM), TLR9 ligand CpG2216 stimulation, VSV-M2 (vesicular stomatitis virus variant 2) infection, or MDA5/TLR3 ligand poly(I:C) stimulation (by >95% inhibition at 9 µM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (≤4.5 µM).

A nonpeptidic thiophenylmethanamine compound that binds interferon-α (K_d = 4 µM for human IFN-α) and prevents IFN-α and IFNAR interaction-dependent IFN-α production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA infection (IC₅₀<4.5 µM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (≤4.5 µM).

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Geppert, T., et al. 2011. Angew. Chem. Int. Ed.51, 258.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable