401474

IKK Inhibitor II, Wedelolactone

The IKK Inhibitor II, Wedelolactone, also referenced under CAS 65646-68-6, controls the biological activity of IKK. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• 別名: IKK Inhibitor II, Wedelolactone, Wedelolactone, Eclipta alba, 7-Methoxy-5,11,12-trihydroxy-coumestan
• 実験式（ヒル表記法）: C₁₆H₁₀O₇
• CAS番号: 524-12-9
• 分子量: 314.25
• MDL番号: MFCD07778564
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: crystalline powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: yellow-green
• 溶解性: methanol: 1 mg/mL; DMSO: 5 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
• InChI Key: XQDCKJKKMFWXGB-UHFFFAOYSA-N

詳細

詳細

Cell-permeable. The naturally-occuring active ingredient from the herbal medicine, Eclipta alba, that acts as a selective and irreversible inhibitor of IKKα and IKKβ kinase activities (IC₅₀<10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Does not affect the activities of p38 MAP kinase or Akt.

The naturally isolated active ingredient of the herbal medicine, Eclipta alba, that acts as a cell permeable, selective and irreversible inhibitor of IKKα and β kinase activity (IC₅₀<10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Has no effects on p38 MAP kinase or Akt.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
IKKα and β kinase activity

Product does not compete with ATP.

Reversible: no

Target IC₅₀: <10 µM against IKKα and β kinase activity

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Kobori, M., et al. 2004. Cell Death Differ.11, 123.
Li, C.C., et al. 2003. J. Org. Chem.68, 8500.
Mors, W.B., et al. 1989. Toxicon27, 1003.
Wagner, H., and Fessler, B. 1986. Planta Med.5, 374.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1