343020

Flt-3 Inhibitor

The Flt-3 Inhibitor, also referenced under CAS 301305-73-7, controls the biological activity of Flt-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: Flt-3 Inhibitor
• 実験式（ヒル表記法）: C₁₈H₂₀N₂O₄S
• CAS番号: 301305-73-7
• 分子量: 360.43
• MDL番号: MFCD00617269
• UNSPSCコード: 12352106
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: <4 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: [s]1c2c(c(c1NC(=O)c3cc(c(cc3)OC)OC)C(=O)N)CCCC2
• InChI: 1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
• InChI Key: FSPQCTGGIANIJZ-UHFFFAOYSA-N

詳細

詳細

A cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC₅₀ = 42 nM) with little effect against a panel of 22 other kinases (IC₅₀ ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC₅₀ = 340 nM) expressing constitutively active Flt-3.

生物化学的／生理学的作用

Cell permeable: yes

Product competes with ATP.

Reversible: no

Target IC₅₀: 42 nM against Flt-3

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

その他情報

Patch, R.J., et al. 2006. Bioorg. Med. Chem. Lett.16, 3282.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3