309866

Diltiazem, Hydrochloride

Synthetic benzothiazepine that acts as an L-type Ca²⁺ channel antagonist.

• 別名: Diltiazem, Hydrochloride, L-Type Calcium Channel Blocker II
• 実験式（ヒル表記法）: C₂₂H₂₆N₂O₄S · xHCl
• CAS番号: 33286-22-5
• 分子量: 414.52 (free base basis)
• MDL番号: MFCD00069252
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 詳細: Merck USA index - 14, 3202
• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: white
• 溶解性: water: 50 mg/mL; chloroform: soluble; methanol: soluble
• 輸送温度: ambient
• 保管温度: 10-30°C
• SMILES記法: S1[C@H]([C@H](C(=O)N(c3c1cccc3)CC[N+H](C)C)OC(=O)C)c2ccc(cc2)OC.[Cl-]
• InChI: 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1
• InChI Key: HDRXZJPWHTXQRI-BHDTVMLSSA-N

詳細

詳細

Synthetic (+)-cis isomer that acts as an L-type Ca²⁺ channel antagonist. Similar in function to nifedipine and verapamil. Has a negative inotropic effect on the heart. Strongly suppresses conductance at the A-V node and automatically at the S-A node. Has also been shown to regulate Ca²⁺ release from intracellular stores in neutrophils.

Synthetic benzothiazepine that acts as an L-type Ca²⁺ channel antagonist. Similar in function to Nifedipine (Cat. No. 481981) and Verapamil (Cat. No. 676777). Has negative inotropic effects on the heart. Strongly suppresses conductance at the A-V node and automaticity at the S-A node. Has also been shown to regulate Ca²⁺ release from intracellular stores in neutrophils.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
L-type Ca2+ channel

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

再構成

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.

その他情報

van Zwieten, P.A., and Pfaffendorf, M. 1993. J. Hypertens. Suppl. 11, S3.
Rosales, C., and Brown, E.J. 1992. J. Biol. Chem. 267, 1443.
Julian, D.G. 1987. Am. J. Cardiol. 59, 37J.
Campbell, K.P., et al. 1986. Proc. Natl. Acad. Sci. USA83, 2792.
Gallizzi, J.P., et al. 1986. J. Biol. Chem.261, 1393.
Garcia, M.L., et al. 1986. J. Biol. Chem.261, 8146.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable