240896

Cystatin C, Human Urine

A low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that it is freely filtered by the glomerular membrane.

• 別名: Post γ-globulin
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥95% (SDS-PAGE)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 溶解性: 0.1 M sodium acetate, pH 4.5: soluble
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

A low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that is freely filtered by the glomerular membrane. Serum levels of cystatin C can be used as a specific and sensitive marker of glomerular filtration rate. Protects organisms against undesirable proteolysis by endogenous or exogenous enzymes. Rapidly and tightly inhibits papain (K_i = 0.26 nM) and cathepsin B (K_i = 4.4 nM). Thought to be linked to many disease processes including Alzheimer′s Disease, hereditary cerebral hemorrhage and lung cancer.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Cysteine protease

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Standard Handling (A)

物理的形状

Lyophilized from 20 mM NH₄HCO₃.

調製ノート

Prepared from the urine of patients with chronic renal tubular proteinuria that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

再構成

Following reconstitution, store in the refrigerator at 4°C. Stock solutions are stable for up to 2 month when stored at -20°C.

その他情報

Hall, A., et al. 1998. Biochemistry37, 4071.
Peloille, S., et al. 1997. Eur. J. Biochem. 244, 140.
Cimerman, N., et al. 1996. Biol. Chem. Hoppe Seyler 377, 19.
Tenstad, O., et al. 1996. Scand. J. Clin. Lab. Invest.56, 409.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable