Lot-specific information can be found on the certificate of analysis (COA). For example, for lot #: 3952706, the specific activity is 3.0 U/mgP, and the pack size is 100 milliunits, which is equivalent to 0.1 units. Therefore, for this specific lot, there is 0.033 mg of protein. In general, for this material, each mg is about 2 to 4 units, so 100 milliunits or 0.1 unit is equivalent to about 0.025 to 0.05 mg amount of protein.
219373
Cathepsin G, Human Neutrophil
Cathepsin G, Human Neutrophil, CAS 107200-92-0, is a purified native cathepsin G. Acts as a potent agonist of human platelet activation leading to their aggregation.
別名:
Cathepsin G, Human Neutrophil
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About This Item
CAS番号:
MDL番号:
UNSPSCコード:
12352202
NACRES:
NA.77
現在、価格および在庫状況を閲覧できません。
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由来生物
human neutrophils
品質水準
詳細
Merck USA index - 14, 1905
アッセイ
≥95% (SDS-PAGE)
フォーム
lyophilized solid (Salt-free)
比活性
≥2 units/mg protein
メーカー／製品名
Calbiochem®
保管条件
OK to freeze
テクニック
inhibition assay: suitable
適合性
suitable for molecular biology
アプリケーション
life science and biopharma
輸送温度
ambient
保管温度
−20°C
遺伝子情報
human ... CTSG(1511)
詳細
Research area: Cell Signaling
Cathepsin G is stored in its active form in azurophil granules of neutrophils or monocytes. Its mature form contains one potential glycan-binding site and three disulfide bonds.[1]
Cathepsin G is stored in its active form in azurophil granules of neutrophils or monocytes. Its mature form contains one potential glycan-binding site and three disulfide bonds.[1]
アプリケーション
生物化学的／生理学的作用
This protease cleaves the triple-helix structure of type I collagen in a restricted manner and degrades nonhelical regions of type I and II collagens, fibronectin, aggrecan, and elastin. Additionally, cathepsin G activates ProMMP-3 and -8.[1] Cathepsin G serves as a chemoattractant for human phagocytes and enhances the random motility of T cells. Additionally, it initiates chemotaxis, activates ERK1/2 and p38 MAPK, and facilitates the translocation of PKCζ to the cell membrane, without inducing a detectable calcium flux.[4] Other biological functions of cathepsin G include: ECM components and plasma proteins degradation, bactericidal actions, cleavage of inflammatory mediators, conversion of angiotensin I to angiotensin II, platelet activation and induction of airway submucosal gland secretion.[5]
警告
Toxicity: Standard Handling (A)
単位の定義
One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol of Suc-AAPF-pNA per min at 25°C, pH 7.5.
調製ノート
Prepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Reconstitute in 150 mM NaCl, 50 mM sodium acetate buffer, pH 5.5.
Reconstitute in 150 mM NaCl, 50 mM sodium acetate buffer, pH 5.5.
再構成
Following reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 6 months at -70°C.
Reconstitute in 50 mM NaOAc and 150 mM NaCl, pH 5.5.
その他情報
Glusa, E., and Adam C. 2001. Por. J. Pharmacol.133, 422.
Shamamian, P., et al. 2001. J. Cell Physiol.189, 197.
Groutas, W.C., et al. 1993. Biochem. Biophys. Res. Commun.197, 730.
Stone, P.J., et al. 1993. Biochem. Biophys. Res. Commun.197, 130.
Groutas, W.C., et al. 1992. Arch. Biochem. Biophys.294, 144.
Maison, C.M., et al. 1991. J. Immunol.147, 921.
Travis, J. 1988. Am. J. Med.84, 37.
Shamamian, P., et al. 2001. J. Cell Physiol.189, 197.
Groutas, W.C., et al. 1993. Biochem. Biophys. Res. Commun.197, 730.
Stone, P.J., et al. 1993. Biochem. Biophys. Res. Commun.197, 130.
Groutas, W.C., et al. 1992. Arch. Biochem. Biophys.294, 144.
Maison, C.M., et al. 1991. J. Immunol.147, 921.
Travis, J. 1988. Am. J. Med.84, 37.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
219373-100MIU:
219373-0U:
219373-500MIU:
219373-U:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Isabelle Migeotte et al.
Cytokine & growth factor reviews, 17(6), 501-519 (2006-11-07)
The formyl peptide receptor (FPR) family is involved in host defence against pathogens, but also in sensing internal molecules that may constitute signals of cellular dysfunction. It includes three subtypes in human and other primates. FPR responds to formyl peptides
Brice Korkmaz et al.
Biochimie, 90(2), 227-242 (2007-11-21)
Polymorphonuclear neutrophils form a primary line of defense against bacterial infections using complementary oxidative and non-oxidative pathways to destroy phagocytized pathogens. The three serine proteases elastase, proteinase 3 and cathepsin G, are major components of the neutrophil primary granules that
Jun Cai et al.
iScience, 27(2), 109005-109005 (2024-02-09)
Endogenous and bacterial proteases play important roles in wound healing and infection. Analysis of alterations in the low-molecular-weight peptidome by individual enzymes could therefore provide insight into proteolytic events occurring in wounds and may aid in the discovery of biomarkers.
Dental and oral biology, biochemistry
Yamakoshi, Y, et al.
reference module in biomedical sciences (2014)
Dieke van der Windt et al.
FEMS immunology and medical microbiology, 66(3), 445-448 (2012-09-05)
Although the Streptococcus pneumoniae polysaccharide capsule is an important virulence factor, ~ 15% of carriage isolates are nonencapsulated. Nonencapsulated S. pneumoniae are a cause of mucosal infections. Recent studies have shown that neutrophils kill S. pneumoniae predominately through neutrophil proteases, such as elastase
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Could you please provide the item number for R: 219373? I recently purchased Human Neutrophil Cathepsin G (219373) with a concentration of 100MIU. I'm experiencing difficulty converting it to µg/ml for the required dilution. Can you assist me with this? Thank you.
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