191500

1-Azakenpaullone

A Kenpaullone analog that acts as a potent and ATP-competitive inhibitor of GSK-3β.

• 別名: 1-Azakenpaullone, 1-AKP
• 実験式（ヒル表記法）: C₁₅H₁₀BrN₃O
• CAS番号: 676596-65-9
• 分子量: 328.16
• MDL番号: MFCD09037522
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥94% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: tan
• 溶解性: DMSO: 100 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
• InChI Key: NTSBZVCEIVPKBJ-UHFFFAOYSA-N

詳細

詳細

A Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC₅₀ = 18 nM), and displays ~100-200 fold greater selectivity over Cdk1/B and Cdk5/p25 (IC₅₀ = 2 µM and 4.2 µM, respectively). Also available as a 10 mM solution in DMSO (Cat. No. 191501).

A Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC₅₀ = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC₅₀ = 2.0 µM and 4.2 µM, respectively).

生物化学的／生理学的作用

Cell permeable: no

Primary Target
GSK-3β

Product competes with ATP.

Reversible: no

Target IC₅₀: 18 nM against GSK-3β

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett.14, 413.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable