189299

ATR/CDK Inhibitor, NU6027

The ATR/CDK Inhibitor, NU6027, also referenced under CAS 220036-08-8, controls the biological activity of ATR/CDK. This small molecule/inhibitor is primarily used for Cancer applications.

• 別名: ATR/CDK Inhibitor, NU6027, ATR Inhibitor, NU6027, 2,6-diamino-4-cyclohexyl-methyloxy-5-nitroso-pyrimidine, CDK2 Inhibitor, NU6027
• 実験式（ヒル表記法）: C₁₁H₁₇N₅O₂
• CAS番号: 220036-08-8
• 分子量: 251.28
• MDL番号: MFCD05664735
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: red-purple
• 溶解性: DMSO: 10 mg/mL, clear, blue
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: Nc1nc(c(c(n1)OCC2CCCCC2)N=O)N
• InChI: 1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
• InChI Key: DGWXOLHKVGDQLN-UHFFFAOYSA-N

詳細

詳細

A cell-permeable, pyrimidine derivative that acts as an ATP-competitive CDK Inhibitor (K_i = 2.5 µM for CDK1, and K_i = 1.3 µM for CDK2), and demonstrates cytostatic properties among a panel of 57 cancer cell lines. Also inhibits ATR kinase (IC₅₀ = 6.7 µM in MCF7 cells), but does not interfere with irradiation-induced autophosphorylation of DNA-PK or ATM. Potentiates a range of DNA-damaging cytotoxic drugs such as hydroxyurea (1.8-fold) and cisplatin (1.4-fold) at 10 µM, but not the anti-mitotic paclitaxel. Attenuates G2/M arrest following DNA damage and inhibits RAD51 focus formation. Shown to be synthetically lethal when DNA single-strand break repair is impaired in PARP-inhibited cells.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

その他情報

Peasland, A., et al. 2011., Br J Cancer. 105, 372.
Arris, C.E, et al. 2000., J Med Chem.43, 2797.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable