169756

Antithrombin III, Human Plasma

Single-chain glycoprotein present in normal serum at about 23 mg/100 ml.

• 別名: Antithrombin III, Human Plasma, ATIII, Heparin cofactor, Factor Xa inhibitor
• CAS番号: 90170-80-2
• MDL番号: MFCD00166632
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• 品質水準: 100
• フォーム: solid
• 比活性: ≥5 units/mg protein
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 溶解性: water: soluble
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

Single chain glycoprotein present in normal serum at about 23 mg/100 ml. Principal physiological inhibitor of thrombin. Present at higher levels in plasma than in serum because it complexes with thrombin during coagulation. Functions by inhibiting proteolytic enzymes involved in blood coagulation and fibrinolysis, including Factor Xa, plasmin, thrombin, and trypsin. Potency is strongly enhanced by heparin.

Single-chain glycoprotein present in normal serum at about 23 mg/100 ml. Principal physiological inhibitor of thrombin. Present at higher levels in plasma than in serum because it complexes with thrombin during coagulation. Functions by inhibiting proteolytic enzymes involved in blood coagulation and fibrinolysis, including Factor Xa, plasmin, thrombin, and trypsin. Potency is strongly enhanced by heparin.

生物化学的／生理学的作用

Cell permeable: no

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Standard Handling (A)

単位の定義

One unit is defined as the amount of antithrombin that will inhibit 1.0 unit of human plasma thrombin present in excess. Thrombin activity is measured using 500 µM tosyl-Gly-Pro-Arg-pNA as substrate in 100 mM Tris-HCl at 25°C, pH 8.2

物理的形状

Lyophilized from 100 mM sodium citrate buffer, 20 mM Tris-HCl, pH 8.3.

調製ノート

Please refer to label for lot-specific volume prior to lyophilization.

アナリシスノート

single band by SDS-PAGE

その他情報

Tsiang, M., et al. 1997. J. Biol. Chem. 272, 12024.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable