119139

Adenosine A₃ Receptor Agonist, 2-Cl-IB-MECA

A highly selective agonist of adenosine A3 receptor (K_i = 330 pM)

• 別名: Adenosine A₃ Receptor Agonist, 2-Cl-IB-MECA
• 実験式（ヒル表記法）: C₁₈H₁₈ClIN₆O₄
• CAS番号: 163042-96-4
• 分子量: 544.73
• MDL番号: MFCD01861178
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 20 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1
• InChI Key: IPSYPUKKXMNCNQ-PFHKOEEOSA-N

詳細

詳細

A highly selective agonist of adenosine A3 receptor (K_i = 330 pM)

An adenosine analog that acts as a highly selective agonist of adenosine A₃ receptor (K_i = 330 pM, 820 nM, 470 nM for A₃, A₁ and A_2A, respectively). Shown to reduce ischemia reperfusion injury in mice and limit infarct size in isolated rat hearts. Shown to reversibly increase field excitatory postsynaptic potentials in hippocampal slices and exhibits excitatory effects on both evoked and spontaneous epileptiform discharges.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Kim, H. O., et al. 1994. J Med Chem.37, 3614.
Laudadio, M. A., et al. 2004. Epilepsy Res.59, 83.
Ge, Z.D., et al. 2006. J. Pharm. Exp. Ther.319, 1200.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable