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アッセイ
>99% (TLC)
フォーム
powder
包装
pkg of 1 × 1 mg (800725P-1mg)
メーカー／製品名
Avanti Research™ - A Croda Brand 800725P
脂質タイプ
phospholipids
cardiolipins
輸送温度
dry ice
保管温度
−20°C
詳細
Lysophosphatidic acid (LPA) receptor modulators include N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid. N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid are competitive inhibitors of the LPA receptor in Xenopus oocytes.[1][2] However, in mammalian cells, N-palmitoyl-tyrosine phosphoric acid may act as an agonist for the LPA receptor.[3] LPA is a lipid mediator that acts similar to growth factors through G-protein coupled plasma membrane receptors.[1][2][4][3] LPA may play a role in platelet aggregation, smooth muscle contraction, vasoactive changes, cytoskeletal reorganization and cell proliferation.[1]
包装
5 mL Amber Glass Screw Cap Vial (800725P-1mg)
調製ノート
Product use: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acid can be used for cell studies.[3] dissolved these lipids in 0.1 mL PBS containing 0.1 mg/mL human serum albumin before adding to cells.[3] In X. laevis studies, these LPA inhibitors were dissolved in DMSO at 1 mM and filtered through a 0.45 mM membrane filter before injection.[2]
法的情報
Avanti Research is a trademark of Avanti Polar Lipids, LLC
保管分類コード
11 - Combustible Solids
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
800725P-1MG:
800725P-BULK:
800725P-VAR:
最新バージョンのいずれかを選択してください：
Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization
An, S
Molecular Pharmacology, 54, 881-888 (1998)
Hydrolysis of phosphatidylserine-exposing red blood cells by secretory phospholipase A2 generates lysophosphatidic acid and results in vascular dysfunction.
Neidlinger, N.A, et. al.
The Journal of Biological Chemistry, 281, 775-781 (2006)
Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids
Bittman, R, et. al.
Journal of Lipid Research, 37, 391-398 (1996)
N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids are selective competitive antagonists of the lysophosphatidic acid receptors
Liliom, K
Molecular Pharmacology, 50, 616-623 (1996)
S An et al.
Molecular pharmacology, 54(5), 881-888 (1998-11-06)
Mobilization of intracellular Ca2+ is a critical cellular response to lysophosphatidic acid (LPA) in many cell types. Recent identification of endothelial differentiation gene (Edg) 2 and Edg4 as subtypes of G protein-coupled receptors for LPA allowed examination of the Ca2+
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