QBD10554

MAL-dPEG^®₂₄-TFP ester

• 実験式（ヒル表記法）: C₆₄H₁₀₈F₄N₂O₂₉
• 分子量: 1445.53
• MDL番号: MFCD28505512
• UNSPSCコード: 12352108
• PubChem Substance ID: 329823943
• NACRES: NA.22

特性

• アッセイ: >90%
• フォーム: solid or viscous liquid
• 反応適合性: reactivity: thiol reactive; reagent type: cross-linking reagent; reactivity: amine reactive
• ポリマー構造: shape: linear; functionality: heterobifunctional
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: O=C(OC1=C(C(F)=CC(F)=C1F)F)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O
• InChI Key: ROVWSNWDFQZUAW-UHFFFAOYSA-N

詳細

特徴および利点

MAL-dPEG^®₂₄-TFP esters is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG^® spacer arm and an amine-reactive active ester on the other end. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. 2,3,5,6-tetrafluorophenyl (TFP) ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG^® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG^® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.

法的情報

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable