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Merck

900393

Sigma-Aldrich

Folate-PEG2000-COOH

average Mn 2,000

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About This Item

化学式:
C19H19N8O5(C2H4O)nC2H3O2
UNSPSCコード:
51171641
NACRES:
NA.23

フォーム

powder

品質水準

分子量

average Mn 2,000

転移温度

Tm 39-49 °C

保管温度

−20°C

アプリケーション

The folate end group may be used for target-specific cellular uptake of drug delivery vehicles and the carboxylate group can be used for further conjugation to make drug conjugates, polymeric nanoparticles, or folate targeting liposomes.[1][2][3][4]

法的情報

Product of JenKem Technology.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


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Slide 1 of 5

1 of 5

Sun Hwa Kim et al.
Langmuir : the ACS journal of surfaces and colloids, 21(19), 8852-8857 (2005-09-07)
Poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles with anionic surface charge were surface coated with cationic di-block copolymer, poly(L-lysine)-poly(ethylene glycol)-folate (PLL-PEG-FOL) conjugate, for enhancing their site-specific intracellular delivery against folate receptor overexpressing cancer cells. The PLGA nanoparticles coated with the conjugate were characterized
Dipanjan Pan et al.
Chemical communications (Cambridge, England), (19)(19), 2400-2401 (2003-11-01)
Shell cross-linked nanoparticles (SCKs) constitute a unique class of materials with amphiphilic core-shell morphology; SCKs are characterised by their structural integrity and available functionality to attach receptor-recognising or receptor-specific ligands on the shell surface and, therefore, hold great potential in
Hyuk Sang Yoo et al.
Journal of controlled release : official journal of the Controlled Release Society, 100(2), 247-256 (2004-11-17)
For folate-receptor-targeted anti-cancer therapy, doxorubicin aggregates in a nano-scale size were produced employing doxorubicin-polyethylene glycol-folate (DOX-PEG-FOL) conjugate. Doxorubicin and folate were respectively conjugated to alpha- and omega-terminal end group of a PEG chain. The conjugates assisted to form doxorubicin nano-aggregates
Da-Wen Dong et al.
Biomaterials, 34(20), 4849-4859 (2013-04-02)
A nanocarrier delivery system that can simultaneously deliver a chemotherapeutic drug and siRNA to the tumor is emerging as a promising treatment strategy for cancer treatment. In this study, a multifunctional PHD/PPF/siRNA complexes was developed by one-step assembly of prefunctionalized

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