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安全性情報

447439

Sigma-Aldrich

1-メチル-L-トリプトファン

95%, for peptide synthesis

別名:

(S)-2-Amino-3-(1-methyl-1H-indol-3-yl)propanoic acid, L-(-)-1-Methyltryptophan

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1 G
￥8,790
5 G
￥29,700

￥8,790

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1 G
￥8,790
5 G
￥29,700

About This Item

実験式（ヒル表記法）:
C12H14N2O2
CAS番号:
21339-55-9
分子量:
218.25
MDL番号:
MFCD00467133
UNSPSCコード:
12352209
PubChem Substance ID:
24868339
NACRES:
NA.22

￥8,790

Check Cart for Availability
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製品名

1-メチル-L-トリプトファン, 95%

品質水準

100

アッセイ

95%

フォーム

solid

光学活性

[α]24/D −8.0°, c = 2 in acetic acid

反応適合性

reaction type: solution phase peptide synthesis

mp

242-245 °C (lit.)

アプリケーション

peptide synthesis

SMILES記法

Cn1cc(C[C@H](N)C(O)=O)c2ccccc12

InChI

1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1

InChI Key

ZADWXFSZEAPBJS-JTQLQIEISA-N

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関連するカテゴリー

アプリケーション

1-メチル-Lトリプトファンの用途：
  • 1,2,3-トリアゾールの位置選択的銅触媒N2-アリール化のためのL-トリプトファンベースの配位子の調製。[1]
  • （-）-アルデミン全合成の重要な出発材料。[2]
  • 薬剤送達システムとしての環状ペプチドキャッピング金ナノ粒子の合成。[3]

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Gloves, type N95 (US)

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

447439-BULK:
447439-1G:
447439-5G:
447439-VAR:

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number
MKCQ0187
MKCJ1127
MKCC7257
MKCC3400
MKBZ4985V

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Slide 1 of 2

1 of 2

キヌレン酸 ≥98%

Sigma-Aldrich

K3375

キヌレン酸

α-(メチルアミノ)イソ酪酸 ≥97% (titration)

Sigma-Aldrich

M2383

α-(メチルアミノ)イソ酪酸

Development of a L?Tryptophan?Based Ligand for Regioselective Copper Catalyzed N2?Arylation of 1, 2, 3?Triazoles.
Lopes A B, et al.
ChemistrySelect, 2(22), 6544-6548 (2017)
Jeroen F J Bogie et al.
Journal of neuroinflammation, 8, 85-85 (2011-07-26)
Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS) in which macrophages play a central role. Initially, macrophages where thought to be merely detrimental in MS, however, recent evidence suggests that their functional phenotype
Christiane A Opitz et al.
PloS one, 6(5), e19823-e19823 (2011-06-01)
1-methyl-D-tryptophan (1-D-MT) is currently being used in clinical trials in patients with relapsed or refractory solid tumors with the aim of inhibiting indoleamine-2,3-dioxygenase (IDO)-mediated tumor immune escape. IDO is expressed in tumors and tumor-draining lymph nodes and degrades tryptophan (trp)
Sergej Tomić et al.
International journal of nanomedicine, 13, 6941-6960 (2018-11-23)
Cellulose nanofibrils (CNF) are attractive nanomaterials for various biomedical applications due to their excellent biocompatibility and biomimetic properties. However, their immunoregulatory properties are insufficiently investigated, especially in relation to their functionalization, which could cause problems during their clinical application. Using
Total synthesis of (?)-ardeemin.
He B, et al.
The Journal of Organic Chemistry, 74(1), 298-304 (2008)
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質問

1–6/6 質問  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 回答

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      役に立ちましたか？

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 回答

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      役に立ちましたか？

  3. What conditions do you recommend for long term storage of Product No. 447439, 1-Methyl-L-tryptophan?

    1 回答

    1. The long term storage temperature of the product 447139 is at room temperature. This information can be found in the MSDS sheet. This document is available from our website.

      役に立ちましたか？

  4. The name of Product No. 447439 is "1-Methyl-L-tryptophan, 95%". How is that purity value determined?

    1 回答

    1. The purity of Product No. 447439 is based on elemental analysis. That is, the assayed values for percent carbon and nitrogen should be within about 95% of their theoretical values. But the speification sheet does not report an overall purity value per se.

      役に立ちましたか？

  5. How do you recommend dissolving Product No. 447439, 1-Methyl-L-tryptophan?

    1 回答

    1. This product is soluble in 0.5 N Hydrochloric acid at 50 mg/mL. Based on information from one of our customers (not confirmed in our labs), this product is also soluble in 0.1 N sodium hydroxide at a 20 mM concentration. It is not soluble in DMSO.

      役に立ちましたか？

  6. What is the Department of Transportation shipping information for this product?

    1 回答

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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