37640

2,8-キノリンジオール

≥99.0% (HPLC)

• 別名: 2,8-ジヒドロキシキノリン
• 実験式（ヒル表記法）: C₉H₇NO₂
• CAS番号: 15450-76-7
• 分子量: 161.16
• Beilstein: 472906
• MDL番号: MFCD00216696
• UNSPSCコード: 12352100
• PubChem Substance ID: 57649744
• NACRES: NA.22

特性

• アッセイ: ≥99.0% (HPLC)
• フォーム: powder
• mp: ~290 °C (dec.)
• SMILES記法: Oc1ccc2cccc(O)c2n1
• InChI: 1S/C9H7NO2/c11-7-3-1-2-6-4-5-8(12)10-9(6)7/h1-5,11H,(H,10,12)
• InChI Key: ZXZKYYHTWHJHFT-UHFFFAOYSA-N

詳細

詳細

2,8-Quinolinediol is a quinolone derivative.[1] It has been reported as metabolite of 8-hydroxyquinoline-N-oxide in rabbits.[1] Synthesis of 2,8-quinolinediol has been reported.[1] It is reported as one of the six possible forms of 8-hydroxycarbostyril.[2] It has been detected as new UV-absorbing compound (UAC) in cow milk and its structure was elucidated using HRMS and by ¹H, ¹³C and ¹H ×¹³C NMR.[3]It is also known as 8-hydroxycarbostyril or 8-hydroxyquinolin-2(1H)-one.[4]

8-hydroxyquinolin-2(1H)-one has been reported as the tautomeric form of 2,8-quinolinediol.[2] 2,8-Quinolinediol (2,8-Dihydroxyquinoline) has been identified as one of the metabolite of quinolone formed in the culture medium of gram-negative bacteria, Pseudomonas stutzeri.[5]

アプリケーション

2,8-Quinolinediol is suitable for use as standard in a study to identify the urinary metabolites for the toxicity related processes and pathogenesis induced by doxorubicin (DOX) to rats by online and off-line LC-MS techniques.[6] It may be used as starting reagent for the preparation of two powerful β2-adrenergic receptor agonists, used for the treatment of asthma:

• Procaterol
• Indacaterol[4]

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves