348902

(S)-(+)-ジヒドロ-5-(ヒドロキシメチル)-2(3H)-フラノン

95%

• 別名: (S)-γ-ヒドロキシメチル-γ-ブチロラクトン, (S)-4,5-ジヒドロ-5-ヒドロキシメチル-2(3H)-フラノン, (S)-5-ヒドロキシメチル-2-オキソテトラヒドロフラン
• 実験式（ヒル表記法）: C₅H₈O₃
• CAS番号: 32780-06-6
• 分子量: 116.12
• Beilstein: 1680284
• MDL番号: MFCD00066224
• UNSPSCコード: 12352005
• PubChem Substance ID: 24861633
• NACRES: NA.22

特性

• アッセイ: 95%
• 形状: liquid
• 光学活性: [α]20/D +56°, c = 3 in chloroform
• 光学純度: ee: 98% (GLC)
• 屈折率: n20/D 1.471 (lit.)
• bp: 110-115 °C/0.2 mmHg (lit.)
• 密度: 1.237 g/mL at 25 °C (lit.)
• 保管温度: 2-8°C
• SMILES記法: OC[C@@H]1CCC(=O)O1
• InChI: 1S/C5H8O3/c6-3-4-1-2-5(7)8-4/h4,6H,1-3H2/t4-/m0/s1
• InChI Key: NSISJFFVIMQBRN-BYPYZUCNSA-N

詳細

詳細

Dihydro-5-(hydroxymethyl)-2(3H)-furanone is a chiral building block widely used in the synthesis of many natural products and few biologically significant compounds like anti-HIV dideoxynucleosides. It is also used in the synthesis of optically active ligands.

アプリケーション

(S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone can be used as a chiral synthon to synthesize:

• Potent nucleoside, acetylcholine, and (+)-muricatacin analogs.
• Mevinic acids, which are LDL cholesterol-lowering agents.
• Adenine based anti-HIV agent named β-F-ddA.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): 235.4 °F - closed cup
• 引火点(℃): 113 °C - closed cup
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)