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アッセイ
≥98%
mp
49-51 °C (lit.)
SMILES記法
[H]O[H].ClCCN(CCCl)P1(=O)NCCCO1
InChI
1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2
InChI Key
PWOQRKCAHTVFLB-UHFFFAOYSA-N
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生物化学的／生理学的作用
シクロホスファミドは、がんの化学療法で広く用いられている細胞毒性ナイトロジェンマスタ-ド誘導体です。DNAと架橋して、鎖の破壊、変異を引き起こします。臨床活性はアルデヒド脱水素酵素1 (ALDH1) 活性の低下と関連しています。
特徴および利点
Cancer research tool.
以下による置換
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Karen Gomez-Mariscal et al.
Annals of clinical and laboratory science, 48(2), 152-157 (2018-04-22)
The aim of the study was to determine if amniotic fluid cells of rats can be used to provide evidence of genotoxicity. In order to do that micronuclei formation was induced in rats during pregnancy after treatment with cyclophosphamide (CP)
Maria Bastaki et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 105, 278-284 (2017-04-30)
Tartrazine is approved as a food color additive internationally with INS number 102, in the United States as food color subject to batch certification "Food, Drug, and Cosmetic" (FD&C) Yellow No. 5, and in Europe as food color additive with
Marie Z Vasquez
Mutagenesis, 25(2), 187-199 (2009-12-09)
Despite regulatory directives requiring the reduction of animal use in safety testing, recent modifications to genotoxicity testing guidelines now propose the use of two in vivo genotoxicity assays as a follow-up to an in vitro positive (International Conference on Harmonization
S Khan et al.
Toxicology international, 20(1), 68-76 (2013-07-09)
Recently, sodium valproate (VPA) has been proven as histone deacetylase (HDAC) inhibitor and potentiates the cytotoxicity of anticancer drugs, and also exhibit promising anti-cancer activity. Present study aimed to investigate the influence of pre- and post-treatment of VPA on cyclophosphamide
Ricardo I Peraza-Vega et al.
Toxicology and industrial health, 33(5), 443-453 (2016-10-26)
The aim of this study was to evaluate the genotoxicity of the herbicide diuron in the wing-spot test and a novel wing imaginal disk comet assay in Drosophila melanogaster. The wing-spot test was performed with standard (ST) and high-bioactivation (HB)
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