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アッセイ
98%
反応適合性
reaction type: click chemistry
bp
123-124 °C (lit.)
密度
1.427 g/mL at 25 °C (lit.)
SMILES記法
CS(F)(=O)=O
InChI
1S/CH3FO2S/c1-5(2,3)4/h1H3
InChI Key
KNWQLFOXPQZGPX-UHFFFAOYSA-N
詳細
Methanesulfonyl fluoride is an anticholinesterase (antiChEs), used to treat Alzheimer′s disease. It is a thrombin inhibitor.
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Acute Tox. 2 Oral - Skin Corr. 1B
保管分類コード
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
労働安全衛生法名称等を表示すべき危険物及び有害物
名称等を表示すべき危険物及び有害物
労働安全衛生法名称等を通知すべき危険物及び有害物
名称等を通知すべき危険物及び有害物
Jan Code
178950-50G:
178950-VAR:
178950-BULK:
178950-25G:
Navid Jamali et al.
Reproductive sciences (Thousand Oaks, Calif.), 28(3), 683-692 (2020-11-04)
Endometriosis, as the leading cause of infertility, is attributed to oxidative stress, inflammation, and autophagy dysregulation. This study was conducted to evaluate the effect of quercetin and metformin, alone or in combination, on the ectopic and eutopic endometrial tissues in
D E Moss et al.
Alzheimer disease and associated disorders, 13(1), 20-25 (1999-04-07)
The purpose of the present study was to evaluate methanesulfonyl fluoride (MSF), a very long-acting CNS-selective acetylcholinesterase (AChE) inhibitor, as a palliative treatment for senile dementia of the Alzheimer type (SDAT). In experiment I, MSF (0.03-0.18 mg/kg) was administered orally
P Masson et al.
Biochimica et biophysica acta, 869(3), 304-313 (1986-02-14)
In order to determine whether a structural modification at the active center of cholinesterase may alter the conformational stability of the enzyme we compared the urea-induced unfolding of the tetrameric form of non-inhibited and irreversibly inhibited human plasma cholinesterase (acylcholine
Tamotsu Imanishi et al.
Advances in pharmacological sciences, 2012, 708178-708178 (2012-02-10)
Anticholinesterases (antiChEs) are used to treat Alzheimer's disease. The comparative effects of two antiChEs, methanesulfonyl fluoride (MSF) and donepezil, on the extracellular levels of ACh in the hippocampus were investigated by in vivo microdialysis in freely moving rats. MSF at
M Shinkai et al.
British journal of pharmacology, 103(1), 1191-1195 (1991-05-01)
1. Contractile responses and acetylcholine release evoked by nicotine in guinea-pig detrusor strips were determined by isotonic transducer and radioimmunoassay, respectively. Nicotine stimulated acetylcholine release and a contractile response in guinea-pig detrusor strips treated with the cholinesterase inhibitor, methanesulphonyl fluoride
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