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Merck

KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

別名:
DFNA2, DFNA2A, KV7.4
Species:
UniProtKB ID:
遺伝子ID:
  • Human(9132) Summary: The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(60613) potassium voltage-gated channel, subfamily Q, member 4
  • Rat(298496) potassium voltage-gated channel, KQT-like subfamily, member 4
  • chicken(419643) potassium voltage-gated channel, KQT-like subfamily, member 4
  • naked mole-rat(101714294) potassium voltage-gated channel, KQT-like subfamily, member 4
  • domestic guinea pig(100716024) potassium voltage-gated channel, KQT-like subfamily, member 4
  • sheep(101122655) potassium voltage-gated channel, KQT-like subfamily, member 4
  • Domestic Rabbit(100358271) potassium voltage-gated channel, KQT-like subfamily, member 4
  • domestic cat(101091641) potassium voltage-gated channel, KQT-like subfamily, member 4
  • Horse(100067963) potassium voltage-gated channel, KQT-like subfamily, member 4
  • cow(528741) potassium voltage-gated channel, KQT-like subfamily, member 4
  • dog(482451) potassium voltage-gated channel, KQT-like subfamily, member 4

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Small Molecule - Activator

製品番号
詳細
Species
BMS 204352, ≥98% (HPLC),
Species
human

Antibodies

製品番号
詳細
交差性
アプリケーション
Monoclonal Anti-KCNQ4 antibody produced in mouse, clone 2H6, purified immunoglobulin, buffered aqueous solution,
交差性
mouse
アプリケーション
ELISA
western blot
抗KCNQ4抗体 ヤギ宿主抗体, affinity isolated antibody, buffered aqueous solution,
交差性
human
アプリケーション
ELISA
western blot

Small Molecule - Blocker

製品番号
詳細
Species
レチガビン, ≥98% (HPLC),
Species
human
レチガビン, analytical standard,
Species
human
グアニジン 塩酸塩, for molecular biology, ≥99%,
Species
human
グアニジン 塩酸塩, ≥98%,
Species
human
グアニジン 塩酸塩, organic base and chaeotropic agent, ≥99% (titration),
Species
human

Small Molecule - Inhibitor

製品番号
詳細
Species
N-エチルマレイミド, crystalline, ≥98% (HPLC),
Species
human

esiRNA

製品番号
詳細
Species
MISSION® esiRNA, targeting human KCNQ4,
Species
human
MISSION® esiRNA, targeting mouse Kcnq4,
Species
mouse